ArticleThe Journal of cell biology2007
Identification of prothymosin-alpha1, the necrosis-apoptosis switch molecule in cortical neuronal cultures.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Effect of prothymosin α on neuroplasticity following cerebral ischemia‑reperfusion injury.Molecular medicine reports · 2024Article
- Non-Vesicular Release of Alarmin Prothymosin α Complex Associated with Annexin-2 Flop-Out.Cells · 2023Review
- Review
- Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity.Mucosal immunology · 2022Article
- Involvement of SNARE Protein Interaction for Non-classical Release of DAMPs/Alarmins Proteins, Prothymosin Alpha and S100A13.Cellular and molecular neurobiology · 2021Article
- Article
- Article
- Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth.JOR spine · 2020Article
- Article
- Critical Functionality Effects from Storage Temperature on Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Suspensions.Scientific reports · 2019Article
- Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Extrathymic production of thymulin induced by oxidative stress, heat shock, apoptosis, or necrosis.International journal of immunopathology and pharmacology · 2017Article
- Subcellular dissemination of prothymosin alpha at normal physiology: immunohistochemical vis-a-vis western blotting perspective.BMC physiology · 2016Article
- Prothymosin Alpha and Immune Responses: Are We Close to Potential Clinical Applications?Vitamins and hormones · 2016Review
- T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.Journal of the American Society of Nephrology : JASN · 2015Article
- An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death.The Journal of biological chemistry · 2015Article
- Photoreceptor cell death and rescue in retinal detachment and degenerations.Progress in retinal and eye research · 2013Review
- New insights into the pathology of podocyte loss: mitotic catastrophe.The American journal of pathology · 2013Review
- Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We initially identified a nuclear protein, prothymosin-alpha1 (ProTalpha), as a key protein inhibiting necrosis by subjecting conditioned media from serum-free cultures of cortical neurons to a few chromatography steps. ProTalpha inhibited necrosis of cultured neurons by preventing rapid loss of cellular adenosine triphosphate levels by reversing the decreased membrane localization of glucose transporters but caused apoptosis through up-regulation of proapoptotic Bcl(2)-family proteins. The apoptosis caused by ProTalpha was further inhibited by growth factors, including brain-derived neurotrophic factor. The ProTalpha-induced cell death mode switch from necrosis to apoptosis was also reproduced in experimental ischemia-reperfusion culture experiments, although the apoptosis level was markedly reduced, possibly because of the presence of growth factors in the reperfused serum. Knock down of PKCbeta(II) expression prevented this cell death mode switch. Collectively, these results suggest that ProTalpha is an extracellular signal protein that acts as a cell death mode switch and could be a promising candidate for preventing brain strokes with the help of known apoptosis inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.