ArticleThe Journal of cell biology2007
Critical requirement for cell cycle inhibitors in sustaining nonproliferative states.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 78 citations in OpenAlex.
- Structural obstruction to full DNA replication in terminally differentiated skeletal muscle cells.EMBO reports · 2025Article
- Role of Annexin 7 (ANXA7) as a Tumor Suppressor and a Regulator of Drug Resistance in Thyroid Cancer.International journal of molecular sciences · 2024Article
- Quiescence-Origin Senescence: A New Paradigm in Cellular Aging.Biomedicines · 2024Article
- Antagonizing Activin A/p15Cells · 2024Article
- Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress.Frontiers in cellular neuroscience · 2022Article
- Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes.Cells · 2021Review
- Article
- A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells.Cell death and differentiation · 2017Article
- Therapeutic targeting of replicative immortality.Seminars in cancer biology · 2015Review
- Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells.Tissue engineering. Part A · 2015Article
- Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis.American journal of physiology. Renal physiology · 2015Article
- Aberrant cell cycle reentry in human and experimental inclusion body myositis and polymyositis.Human molecular genetics · 2014Article
- Modelling mammalian cellular quiescence.Interface focus · 2014Review
- Article
- Poly(ADP-ribosyl)ation is required to modulate chromatin changes at c-MYC promoter during emergence from quiescence.PloS one · 2014Article
- Cyclin D1 is a major target of miR-206 in cell differentiation and transformation.Cell cycle (Georgetown, Tex.) · 2013Article
- Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity.Cell death and differentiation · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In adult vertebrates, most cells are not in the cell cycle at any one time. Physiological nonproliferation states encompass reversible quiescence and permanent postmitotic conditions such as terminal differentiation and replicative senescence. Although these states appear to be attained and maintained quite differently, they might share a core proliferation-restricting mechanism. Unexpectedly, we found that all sorts of nonproliferating cells can be mitotically reactivated by the sole suppression of histotype-specific cyclin-dependent kinase (cdk) inhibitors (CKIs) in the absence of exogenous mitogens. RNA interference-mediated suppression of appropriate CKIs efficiently triggered DNA synthesis and mitosis in established and primary terminally differentiated skeletal muscle cells (myotubes), quiescent human fibroblasts, and senescent human embryo kidney cells. In serum-starved fibroblasts and myotubes alike, cell cycle reactivation was critically mediated by the derepression of cyclin D-cdk4/6 complexes. Thus, both temporary and permanent growth arrest must be actively maintained by the constant expression of CKIs, whereas the cell cycle-driving cyclins are always present or can be readily elicited. In principle, our findings could find wide application in biotechnology and tissue repair whenever cell proliferation is limiting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.