ArticleInfection and immunity2007
Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Prevalence of the JP2 genotype of Aggregatibacter actinomycetemcomitans in the world population: a systematic review.Clinical oral investigations · 2022Pooled it
- The genomic history of Streptococcus mutans from the Mesolithic until modern times.Genome biology · 2026Article
- Immunological Diagnosis and Treatments of Periodontitis in Patients with Type 2 Diabetes Mellitus.Advances in experimental medicine and biology · 2026Review
- Molecular Analysis ofPathogens (Basel, Switzerland) · 2024Article
- A Rose by Any Other Name: The Long Intricate History of Localized Aggressive Periodontitis.Pathogens (Basel, Switzerland) · 2024Review
- From Global to Nano: A Geographical Perspective ofPathogens (Basel, Switzerland) · 2024Review
- Grade C Molar-Incisor Pattern Periodontitis in Young Adults: What Have We Learned So Far?Pathogens (Basel, Switzerland) · 2024Review
- Leukotoxin A Production and Release by JP2 and Non-JP2 GenotypePathogens (Basel, Switzerland) · 2024Article
- Toxin-triggered liposomes for the controlled release of antibiotics to treat infections associated with the gram-negative bacterium, Aggregatibacter actinomycetemcomitans.Colloids and surfaces. B, Biointerfaces · 2024Article
- Heterogeneity of Size and Toxin Distribution inToxins · 2024Article
- qPCR Detection and Quantification ofPathogens (Basel, Switzerland) · 2023Article
- Carriage of the JP2 Genotype ofPathogens (Basel, Switzerland) · 2022Article
- Proteomic Characterization of the Oral PathogenPathogens (Basel, Switzerland) · 2022Article
- The Highly Leukotoxic JP2 Genotype ofPathogens (Basel, Switzerland) · 2022Article
- Discrepancies in Antimicrobial Susceptibility between the JP2 and the Non-JP2 Genotype ofAntibiotics (Basel, Switzerland) · 2022Article
- Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research.Advances in experimental medicine and biology · 2022Article
- Multilocus Sequence Typing of Aggregatibacter actinomycetemcomitans Competently Depicts the Population Structure of the Species.Microbiology spectrum · 2021Article
- Article
- Etiology of aggressive periodontitis in individuals of African descent.The Japanese dental science review · 2021Review
- Prevalence of JP2 and Non-JP2 Genotypes ofPathogens (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural history, microevolution, and patterns of interindividual transmission and global dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans were studied by population genetic analysis. The JP2 clone is strongly associated with aggressive periodontitis in adolescents of African descent and differs from other clones of the species by several genetic peculiarities, including a 530-bp deletion in the promoter region of the leukotoxin gene operon, which results in increased leukotoxic activity. Multilocus sequence analysis of 82 A. actinomycetemcomitans strains, 66 of which were JP2 clone strains collected over a period of more than 20 years, confirmed that there is a clonal population structure with evolutionary lineages corresponding to serotypes. Although genetically highly conserved, as shown by alignment of sequences of eight housekeeping genes, strains belonging to the JP2 clone had a number of point mutations, particularly in the pseudogenes hbpA and tbpA. Characteristic mutations allowed isolates from individuals from the Mediterranean area and from West Africa, including the Cape Verde Islands, to be distinguished. The patterns of mutations indicate that the JP2 clone initially emerged as a distinct genotype in the Mediterranean part of Africa approximately 2,400 years ago and subsequently spread to West Africa, from which it was transferred to the American continents during the transatlantic slave trade. The sustained exclusive colonization of individuals of African descent despite geographical separation for centuries suggests that the JP2 clone has a distinct host tropism. The colonization of family members by JP2 clone strains with unique point mutations provides strong evidence that there is intrafamilial transmission and suggests that dissemination of the JP2 clone is restricted to close contacts.
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