ArticleMolecular and cellular biology2007
Mbd2 contributes to DNA methylation-directed repression of the Xist gene.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation.Nature communications · 2026Article
- Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition.Experimental & molecular medicine · 2024Article
- Toxicity of DON on GPx1-Overexpressed or Knockdown Porcine Splenic Lymphocytes In Vitro and Protective Effects of Sodium Selenite.Oxidative medicine and cellular longevity · 2019Article
- Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer.Oncogene · 2017Article
- MiR-520b inhibits the development of glioma by directly targeting MBD2.American journal of cancer research · 2017Article
- MBD2 as a novel marker associated with poor survival of patients with hepatocellular carcinoma after hepatic resection.Molecular medicine reports · 2016Article
- Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions.Epigenomics · 2016Article
- Divergent actions of long noncoding RNAs on X-chromosome remodelling in mammals and Drosophila achieve the same end result: dosage compensation.Journal of genetics · 2015Review
- Epigenetic modulation of insulin-like growth factor-II overexpression by hepatitis B virus X protein in hepatocellular carcinoma.American journal of cancer research · 2015Article
- Article
- MBD2 and MBD3: elusive functions and mechanisms.Frontiers in genetics · 2014Review
- Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females.PLoS genetics · 2013Article
- How is epigenetic information maintained through DNA replication?Epigenetics & chromatin · 2013Article
- Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice.Genes & development · 2011Article
- The single active X in human cells: evolutionary tinkering personified.Human genetics · 2011Review
- Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA.Nucleic acids research · 2010Article
- Experimental approaches to the study of epigenomic dysregulation in ageing.Experimental gerontology · 2010Review
- A role for methyl-CpG binding domain protein 2 in the modulation of the estrogen response of pS2/TFF1 gene.PloS one · 2010Article
- Article
- Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma.BMC medical genomics · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown. As methylated DNA binding proteins (MBPs) are potential mediators of gene silencing by DNA methylation, we asked whether MBP-deficient cell lines could maintain Xist repression. The absence of Mbd2 caused significant low-level reactivation of Xist, but silencing was restored by exogenous Mbd2. In contrast, deficiencies of Mbd1, MeCP2, and Kaiso had no detectable effect, indicating that MBPs are not functionally redundant at this locus. Xist repression in Mbd2-null cells was hypersensitive to the histone deacetylase inhibitor trichostatin A and to depletion of the DNA methyltransferase Dnmt1. These synergies implicate Mbd2 as a mediator of the DNA methylation signal at this locus. The presence of redundant mechanisms to enforce repression at Xist and other loci is compatible with the hypothesis that "stacking" of imperfect repressive tendencies may be an evolutionary strategy to ensure leakproof gene silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.