ArticleMolecular and cellular biology2007
MBD2 is required for correct spatial gene expression in the gut.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- SMURF: soft-segmentation for single-cell reconstruction and topological analysis of spatial transcriptomic data.Nature communications · 2026Article
- DNA Methylation Modulates Aging Process in Adipocytes.Aging and disease · 2022Review
- Stromal-associated cytokines bias the interplay between gene expression and DNA methylation in human breast cancers.Epigenetics · 2020Article
- Deciphering GRINA/Lifeguard1: Nuclear Location, CaInternational journal of molecular sciences · 2019Review
- Epigenetic silencing of serine protease HTRA1 drives polyploidy.BMC cancer · 2016Article
- Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions.Epigenomics · 2016Article
- Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation.Frontiers in genetics · 2016Review
- Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells.Nucleic acids research · 2015Article
- An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.Nucleic acids research · 2015Article
- Epigenetic modulation of intestinal cholesterol transporter Niemann-Pick C1-like 1 (NPC1L1) gene expression by DNA methylation.The Journal of biological chemistry · 2014Article
- Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence.Nucleic acids research · 2011Article
- Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA.Nucleic acids research · 2010Article
- Deficiency of Mbd2 attenuates Wnt signaling.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Gene expression in the gut is segmentally regulated, but little is known of the molecular origin of patterning. Analysis of gene expression in colons from mice lacking the methyl-CpG binding repressor MBD2 revealed frequent activation of genes that are normally only expressed in the exocrine pancreas and duodenum. Reduced DNA methylation activated the same gene set in the colon. No significant differences in DNA methylation between the colon and duodenum were detected, but MBD2 was significantly more abundant in the colon. The relevance of MBD2 concentration was tested in a human colon cancer cell line. Depletion of MBD2 was again found to activate exocrine pancreatic genes. Gene activation in this cell culture model was accompanied by loss of promoter-bound MBD2 and increased histone acetylation. The results suggest that modulation of MBD2 during gut development establishes a region-specific gene expression pattern that is essential for establishing correct segmental character.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.