ArticleAntimicrobial agents and chemotherapy2007
Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 105 citations in OpenAlex.
- The Global Challenge ofTropical medicine and infectious disease · 2025Review
- Antibiotic use in the commercial poultry sector of Uganda and its public health implications: a cross-sectional survey.BMJ public health · 2025Article
- Porcine carcasses as an underestimated source of antimicrobial resistantJournal of veterinary research · 2023Article
- Recurrent Campylobacter jejuni Infections withMicrobiology spectrum · 2023Article
- Genomic Characterization of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Tryptanthrin Reduces Campylobacter jejuni Colonization in the Chicken Gut by a Bactericidal Mechanism.Applied and environmental microbiology · 2023Article
- Antimicrobial effect of a drinking water additive comprising four organic acids on Campylobacter load in broilers and monitoring of bacterial susceptibility.Poultry science · 2022Article
- Antibiotic Resistance in Bacteria-A Review.Antibiotics (Basel, Switzerland) · 2022Review
- Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data-Part II, Application.Pathogens (Basel, Switzerland) · 2021Article
- Antimicrobial Resistance, FlaA Sequencing, and Phylogenetic Analysis ofVeterinary sciences · 2021Article
- Core Genome Multilocus Sequence Typing for Food Animal Source Attribution of HumanPathogens (Basel, Switzerland) · 2020Article
- Prevalence, seasonality, and antimicrobial resistance of thermotolerantVeterinary world · 2020Article
- Antimicrobial Resistance in Veterinary Medicine: An Overview.International journal of molecular sciences · 2020Review
- Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases.PloS one · 2020Article
- A Historical Review on Antibiotic Resistance of FoodborneFrontiers in microbiology · 2019Review
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Molecular Basis of Macrolide Resistance inBioMed research international · 2018Article
- The effects of different enrofloxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonella Typhimurium.Scientific reports · 2017Article
- The Current State of Macrolide Resistance in Campylobacter spp.: Trends and Impacts of Resistance Mechanisms.Applied and environmental microbiology · 2017Review
- Phenotypic and Transcriptomic Responses ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work we conducted both in vitro and in vivo experiments to examine the development and mechanisms of erythromycin (Ery) resistance in Campylobacter jejuni and Campylobacter coli. In vitro plating revealed that both Campylobacter species had similar but low spontaneous mutation frequencies (3 x 10(-9) to <5.41 x 10(-10)) for Ery resistance. Chickens infected with C. jejuni or C. coli were subjected to single or multiple treatments with medicated water containing tylosin (0.53 g/liter), which transiently reduced the level of Campylobacter colonization but did not select for Ery-resistant (Ery(r)) mutants in the treated birds. However, when tylosin was given to the chickens in feed at a growth-promoting dose (0.05 g/kg feed), Ery(r) mutants emerged in the birds after prolonged exposure to the antibiotic. The vast majority of the in vitro- and in vivo-selected Campylobacter mutants with Ery MICs of 8 to 256 microg/ml lacked the known resistance-associated mutations in the 23S rRNA gene, while the highly resistant mutants (Ery MIC > 512 microg/ml) had the A2074G mutation in the 23S rRNA gene. Inactivation of CmeABC, a multidrug efflux pump, dramatically reduced the Ery MIC in all of the examined mutants regardless of the presence of the A2074G mutation. Together, these results reveal distinct features associated with Ery resistance development in Campylobacter, demonstrate the significant role of CmeABC in Ery resistance, and suggest that long-term use of a macrolide as a growth promoter selects for the emergence of Ery(r) Campylobacter in animal reservoirs.
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