Evidence map›Paper›PMID 17352902›Full record

ReviewAdvances in genetics2007

Enabling a community to dissect an organism: overview of the Neurospora functional genomics project.

Jay C Dunlap, Katherine A Borkovich, Matthew R Henn, Gloria E Turner, Matthew S Sachs, N Louise Glass, Kevin McCluskey, Michael Plamann, James E Galagan, Bruce W Birren and 25 more

Open access · greenAbstract readReview
In one paragraph

Review in Advances in genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 225 citations in OpenAlex.

  1. Barcoded mutant library enables high-throughput functional genomics in a filamentous fungus.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  6. Computational and structural biotechnology journal · 2026
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  12. The First Observation of the Filamentous FungusJournal of fungi (Basel, Switzerland) · 2024
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 9 institutions in 1 country.

Jay C DunlapDepartment of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
Katherine A Borkovich
Matthew R Henn
Gloria E Turner
Matthew S Sachs
N Louise Glass
Kevin McCluskey
Michael Plamann
James E Galagan
Bruce W Birren
Richard L Weiss
Jeffrey P Townsend
Jennifer J Loros
Mary Anne Nelson
Randy Lambreghts
Hildur V Colot
Gyungsoon Park
Patrick Collopy
Carol Ringelberg
Christopher Crew
Liubov Litvinkova
Dave DeCaprio
Heather M Hood
Susan Curilla
Mi Shi
Matthew Crawford
Michael Koerhsen
Phil Montgomery
Lisa Larson
Matthew Pearson
Takao Kasuga
Chaoguang Tian
Meray Baştürkmen
Lorena Altamirano
Junhuan Xu
Broad Institute · USDartmouth College · USUniversity of California, Riverside · USOregon Health & Science University · USUniversity of California, Berkeley · USUniversity of California, Los Angeles · USUniversity of Missouri–Kansas City · USUniversity of New Mexico · USYale University · US

Funding

Tools for Functional Analysis and Cell BiologyP01GM068087 · NIGMS · DARTMOUTH COLLEGE · PI DUNLAP, JAY C. · 2004 to 2013
$19.3M
UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCKR01GM034985 · NIGMS · DARTMOUTH COLLEGE · PI DUNLAP, JAY C. · 1986 to 2015
$5.7M
UCLA Bridges to the Baccalaureate ProgramR25GM050067 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIMMONS, DWAYNE D · 1993 to 2015
$2.3M
Systems Biology of the Circadian Clock Output NetworkR01GM113673 · NIGMS · TEXAS A&M UNIVERSITY · PI BELL-PEDERSEN, DEBORAH, GALAGAN, JAMES E · 2015 to 2018
$1.6M
NIGMS NIH HHS 5 R25 GM050067NIGMS NIH HHS 5 R25 GM055052NIGMS NIH HHS P01 GM068087NIGMS NIH HHS R01 GM034985NIGMS NIH HHS R01 GM113673NIGMS NIH HHS R25 GM050067NIGMS NIH HHS R25 GM055052
6 · The paper itself

Abstract

A consortium of investigators is engaged in a functional genomics project centered on the filamentous fungus Neurospora, with an eye to opening up the functional genomic analysis of all the filamentous fungi. The overall goal of the four interdependent projects in this effort is to accomplish functional genomics, annotation, and expression analyses of Neurospora crassa, a filamentous fungus that is an established model for the assemblage of over 250,000 species of non yeast fungi. Building from the completely sequenced 43-Mb Neurospora genome, Project 1 is pursuing the systematic disruption of genes through targeted gene replacements, phenotypic analysis of mutant strains, and their distribution to the scientific community at large. Project 2, through a primary focus in Annotation and Bioinformatics, has developed a platform for electronically capturing community feedback and data about the existing annotation, while building and maintaining a database to capture and display information about phenotypes. Oligonucleotide-based microarrays created in Project 3 are being used to collect baseline expression data for the nearly 11,000 distinguishable transcripts in Neurospora under various conditions of growth and development, and eventually to begin to analyze the global effects of loss of novel genes in strains created by Project 1. cDNA libraries generated in Project 4 document the overall complexity of expressed sequences in Neurospora, including alternative splicing alternative promoters and antisense transcripts. In addition, these studies have driven the assembly of an SNP map presently populated by nearly 300 markers that will greatly accelerate the positional cloning of genes.

Indexed as

Base SequenceChromosome MappingDNA, FungalGene DeletionGene Expression ProfilingGene LibraryGenetic TechniquesGenome, FungalGenomicsMutationNeurosporaOligonucleotide Array Sequence AnalysisPhenotypePolymorphism, Single NucleotideDNA, Fungal

Identifiers

PMID17352902
PMCPMC3673015
OpenAlexW1496662040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.