ArticleGenome biology2007
New genes in the evolution of the neural crest differentiation program.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 50 citations in OpenAlex.
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- Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diversifying Selection Between Pure-Breed and Free-Breeding Dogs Inferred from Genome-Wide SNP Analysis.G3 (Bethesda, Md.) · 2016Article
- Characterization of the trunk neural crest in the bamboo shark, Chiloscyllium punctatum.The Journal of comparative neurology · 2013Article
- Progenitors of the protochordate ocellus as an evolutionary origin of the neural crest.EvoDevo · 2013Article
- Incremental evolution of the neural crest, neural crest cells and neural crest-derived skeletal tissues.Journal of anatomy · 2013Review
- New perspectives on pharyngeal dorsoventral patterning in development and evolution of the vertebrate jaw.Developmental biology · 2012Review
- Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila.Cell reports · 2012Article
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- Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma.Neoplasia (New York, N.Y.) · 2010Article
- Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression.Neoplasia (New York, N.Y.) · 2009Article
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- Insights from the amphioxus genome on the origin of vertebrate neural crest.Genome research · 2008Article
- The origin and evolution of the neural crest.BioEssays : news and reviews in molecular, cellular and developmental biology · 2008Review
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- The mammalian phenotype ontology: enabling robust annotation and comparative analysis.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopment of the vertebrate head depends on the multipotency and migratory behavior of neural crest derivatives. This cell population is considered a vertebrate innovation and, accordingly, chordate ancestors lacked neural crest counterparts. The identification of neural crest specification genes expressed in the neural plate of basal chordates, in addition to the discovery of pigmented migratory cells in ascidians, has challenged this hypothesis. These new findings revive the debate on what is new and what is ancient in the genetic program that controls neural crest formation.
resultsTo determine the origin of neural crest genes, we analyzed Phenotype Ontology annotations to select genes that control the development of this tissue. Using a sequential blast pipeline, we phylogenetically classified these genes, as well as those associated with other tissues, in order to define tissue-specific profiles of gene emergence. Of neural crest genes, 9% are vertebrate innovations. Our comparative analyses show that, among different tissues, the neural crest exhibits a particularly high rate of gene emergence during vertebrate evolution. A remarkable proportion of the new neural crest genes encode soluble ligands that control neural crest precursor specification into each cell lineage, including pigmented, neural, glial, and skeletal derivatives.
conclusionWe propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population.
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