ArticlePLoS genetics2007
Live hot, die young: transmission distortion in recombination hotspots.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 119 citations in OpenAlex.
- Why recombination hotspots?PLoS genetics · 2026Review
- The SHR/Akr Y chromosome reveals repeated turnover of the rat pseudoautosomal region.bioRxiv : the preprint server for biology · 2025Article
- Article
- Understanding the Genetic Basis of Variation in Meiotic Recombination: Past, Present, and Future.Molecular biology and evolution · 2024Review
- Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features.Science (New York, N.Y.) · 2024Article
- Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line.Science (New York, N.Y.) · 2023Article
- Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence.eLife · 2023Article
- Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features.bioRxiv : the preprint server for biology · 2023Article
- Recombination hotspots in soybean [Glycine max (L.) Merr.].G3 (Bethesda, Md.) · 2023Article
- Article
- Population Genomics in the Great Apes.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations.Science advances · 2019Article
- PRDM9 Diversity at Fine Geographical Scale Reveals Contrasting Evolutionary Patterns and Functional Constraints in Natural Populations of House Mice.Molecular biology and evolution · 2019Article
- LDJump: Estimating variable recombination rates from population genetic data.Molecular ecology resources · 2019Article
- Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm.Science (New York, N.Y.) · 2019Article
- Evolution of the Yeast Recombination Landscape.Molecular biology and evolution · 2019Article
- Recombination hotspots in an extended human pseudoautosomal domain predicted from double-strand break maps and characterized by sperm-based crossover analysis.PLoS genetics · 2018Article
- PRDM9, a driver of the genetic map.PLoS genetics · 2018Review
- Characterization of recombination features and the genetic basis in multiple cattle breeds.BMC genomics · 2018Article
- Hotspots for Initiation of Meiotic Recombination.Frontiers in genetics · 2018Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
There is strong evidence that hotspots of meiotic recombination in humans are transient features of the genome. For example, hotspot locations are not shared between human and chimpanzee. Biased gene conversion in favor of alleles that locally disrupt hotspots is a possible explanation of the short lifespan of hotspots. We investigate the implications of such a bias on human hotspots and their evolution. Our results demonstrate that gene conversion bias is a sufficiently strong force to produce the observed lack of sharing of intense hotspots between species, although sharing may be much more common for weaker hotspots. We investigate models of how hotspots arise, and find that only models in which hotspot alleles do not initially experience drive are consistent with observations of rather hot hotspots in the human genome. Mutations acting against drive cannot successfully introduce such hotspots into the population, even if there is direct selection for higher recombination rates, such as to ensure correct segregation during meiosis. We explore the impact of hotspot alleles on patterns of haplotype variation, and show that such alleles mask their presence in population genetic data, making them difficult to detect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.