ArticleEuropean journal of obstetrics, gynecology, and reproductive biology2008
Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model.
Article in European journal of obstetrics, gynecology, and reproductive biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06064669 (Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Oral anti-diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning pregnancy, or pregnant women with pre-existing diabetes.The Cochrane database of systematic reviews · 2017 · on this mapPooled it
- Metformin vs insulin in the management of gestational diabetes: a meta-analysis.PloS one · 2013 · on this mapPooled it
- Oral anti-diabetic agents for women with pre-existing diabetes mellitus/impaired glucose tolerance or previous gestational diabetes mellitus.The Cochrane database of systematic reviews · 2010Pooled it
- Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure.CPT: pharmacometrics & systems pharmacology · 2026Article
- Metformin modulates oxidative stress via activation of AMPK/NF-κB signaling in Trisomy 21 fibroblasts: anFrontiers in molecular biosciences · 2025Article
- AMPK Phosphorylates LMX1b to Regulate a Brainstem Neurogenic Network Important for Control of Breathing in Neonatal Mice.International journal of molecular sciences · 2024Article
- Article
- Position paper of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), and the Italian Study Group of Diabetes in pregnancy: Metformin use in pregnancy.Acta diabetologica · 2023Review
- Prediction of Maternal and Fetal Acyclovir, Emtricitabine, Lamivudine, and Metformin Concentrations during Pregnancy Using a Physiologically Based Pharmacokinetic Modeling Approach.Clinical pharmacokinetics · 2022Article
- Organic Cation Transporter 3 Facilitates Fetal Exposure to Metformin during Pregnancy.Molecular pharmacology · 2018Article
- Oral Agents for the Treatment of Gestational Diabetes.Current diabetes reports · 2018Review
- Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study.BMJ (Clinical research ed.) · 2018Article
- Gestational diabetes mellitus management with oral hypoglycemic agents.Seminars in perinatology · 2014Review
- Neonatal outcomes in women with gestational diabetes mellitus treated with metformin in compare with insulin: A randomized clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation.Annals of translational medicine · 2014Review
- The placenta in toxicology. Part IV: Battery of toxicological test systems based on human placenta.Toxicologic pathology · 2014Review
- Metformin pharmacokinetics in nondiabetic pregnant women with polycystic ovary syndrome.European journal of clinical pharmacology · 2011Article
- Gestational diabetes mellitus: Non-insulin management.Indian journal of endocrinology and metabolism · 2011Article
- Antibiotic Treatment of Dogs and Cats during Pregnancy.Veterinary medicine international · 2010Article
- Comparison of metformin and insulin in the treatment of gestational diabetes: a retrospective, case-control study.The review of diabetic studies : RDS · 2008 · on this mapArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the study was to quantify and characterize metformin transfer across the human placenta using an ex vivo placental perfusion model. STUDY
designPlacentas were obtained from vaginal deliveries or caesarean sections and selected cotyledons were cannulated and dually perfused. Metformin (1 microg/ml) and a permeability reference marker, antipyrine (50 microg/ml), were added to the maternal circulation. Each perfusion experiment was conducted for 180 min while samples were taken from the maternal and fetal compartments. The integrity and viability of the placenta were determined by measuring the flow rates, fetal artery inflow pressure, and hCG production during the experiments.
resultsSix complete experimental set-ups were completed. The maternal-fetal transport rates for metformin and antipyrine were 10.61+/-2.85% and 30.98+/-5.62%, respectively. The clearance index, calculated as the ratio between the permeabilities of metformin and antipyrine, was 0.34+/-0.05.
conclusionThe results indicate that metformin is able to cross the mature human placenta; thus, fetal exposure must be considered when treating pregnant women with metformin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.