ArticlePharmacology, biochemistry, and behavior2007
NMDA receptor in conditioned flavor-taste preference learning: blockade by MK-801 and enhancement by D-cycloserine.
Article in Pharmacology, biochemistry, and behavior, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Human perceptual learning is delayed by the N-methyl-D-aspartate receptor partial agonist D-cycloserine.Journal of psychopharmacology (Oxford, England) · 2021Trial
- A randomized, placebo-controlled laboratory study of the effects of D-cycloserine on sexual memory consolidation in women.Psychopharmacology · 2020Trial
- The NMDA receptor partial agonist d-cycloserine does not enhance motor learning.Journal of psychopharmacology (Oxford, England) · 2016Trial
- A role beyond learning for NMDA receptors in reward-based decision-making-a pharmacological study using d-cycloserine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Forty-eight hour conditioning produces a robust long lasting flavor preference in rats.Appetite · 2019Article
- Dopamine receptor signaling in the medial orbital frontal cortex and the acquisition and expression of fructose-conditioned flavor preferences in rats.Brain research · 2015Article
- D-cycloserine in prelimbic cortex reverses scopolamine-induced deficits in olfactory memory in rats.PloS one · 2013Article
- Critical role of NMDA but not opioid receptors in the acquisition of fat-conditioned flavor preferences in rats.Neurobiology of learning and memory · 2012Article
- Strain differences in sucrose- and fructose-conditioned flavor preferences in mice.Physiology & behavior · 2012Article
- Dopamine and learned food preferences.Physiology & behavior · 2011Review
- Effects of pharmacological manipulations of NMDA-receptors on deliberation in the Multiple-T task.Neurobiology of learning and memory · 2011Article
- Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats.Neurobiology of learning and memory · 2011Article
- Neuropharmacology of learned flavor preferences.Pharmacology, biochemistry, and behavior · 2010Review
- Opioid receptor antagonism in the nucleus accumbens fails to block the expression of sugar-conditioned flavor preferences in rats.Pharmacology, biochemistry, and behavior · 2010Article
- Disruption of Long-Term Alcohol-Related Memory Reconsolidation: Role of β-Adrenoceptors and NMDA Receptors.Frontiers in behavioral neuroscience · 2010Article
- Role of amygdala dopamine D1 and D2 receptors in the acquisition and expression of fructose-conditioned flavor preferences in rats.Behavioural brain research · 2009Article
- Rapid acquisition of conditioned flavor preferences in rats.Physiology & behavior · 2009Article
- Role of systemic endocannabinoid CB-1 receptor antagonism in the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats.Pharmacology, biochemistry, and behavior · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Conditioned flavor-taste preference (CFTP) is a robust form of learning in which animals acquire a preference for a flavor (e.g. Kool-Aid) previously mixed with a highly preferred tastant (e.g. fructose) over a flavor previously mixed with a less-preferred tastant (e.g. saccharin). Here, the role of the N-methyl-D-aspartate (NMDA) glutamate-glycine receptor (NR) was probed using systemic MK-801, a non-competitive antagonist, and D-cycloserine (DCS), a glycine agonist. Rats were injected with MK-801 (100 microg/kg) or vehicle 30 min prior to a daily 2-h conditioning session with 1-bottle access to a Kool-Aid flavor (grape or cherry) mixed with either 8% fructose (CS+/F) or 0.2% saccharin (CS-/S). CFTP expression was measured in 2-bottle preference tests between the Kool-Aid flavors mixed with 0.2% saccharin (CS+/S vs. CS-/S). While vehicle-treated rats acquired a preference for CS+/S over CS-/S, MK-801 prior to conditioning completely blocked CFTP learning. The effect of MK-801 was specific to CFTP acquisition, because follow-up experiments demonstrated that MK-801 did not induce a conditioned taste aversion, cause state-dependent learning, or affect CFTP expression. In a second approach, rats were injected with DCS (15 mg/kg) 60 min prior to daily conditioning. In contrast to MK-801, administration of DCS prior to conditioning enhanced CFTP learning (but not reversal conditioning). These results demonstrate that NR neurotransmission is critical for CFTP learning. Furthermore, enhancement of CFTP learning by DCS suggests that endogenous levels of glycine or D-serine may be a limiting factor in CFTP learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.