ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2007
Anoxia-induced changes in reactive oxygen species and cyclic nucleotides in the painted turtle.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 67 citations in OpenAlex.
- A new chromosome-level genome assembly for western painted turtle Chrysemys picta bellii, a model for extreme physiological adaptations.BMC genomics · 2026Article
- A primary neuron culture system for functional studies of anoxia tolerance in turtles.The Journal of experimental biology · 2025Article
- Metabolomic Profiling Reveals Differences in Hypoxia Response between Far Eastern and Siberian Frogs.Animals : an open access journal from MDPI · 2023Article
- Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts.The Journal of experimental biology · 2023Article
- Naked Mole-Rat Cortex Maintains Reactive Oxygen Species Homeostasis DuringCurrent neuropharmacology · 2023Article
- Indirect evidence that anoxia exposure and cold acclimation alter transarcolemmal CaComparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2021Article
- Cytoskeletal Arrest: An Anoxia Tolerance Mechanism.Metabolites · 2021Review
- Differential Responses of Methionine Sulfoxide Reductases A and B to Anoxia and Oxidative Stress in the Freshwater TurtleMetabolites · 2021Article
- Induction of foxo3a protects turtle neurons against oxidative stress.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2020Article
- Oxygen-sensitive interneurons exhibit increased activity and GABA release during ROS scavenging in the cerebral cortex of the western painted turtle.Journal of neurophysiology · 2019Article
- Developmental plasticity of cardiac anoxia-tolerance in juvenile common snapping turtles ( Chelydra serpentina).Proceedings. Biological sciences · 2019Article
- Mitochondrial matrix pH acidifies during anoxia and is maintained by the FFEBS open bio · 2019Article
- Effects of cold on murine brain mitochondrial function.PloS one · 2018Article
- Effects of Military activity and habitat quality on DNA damage and oxidative stress in the largest population of the Federally threatened gopher tortoise.Ecotoxicology (London, England) · 2017Article
- Salinity stress from the perspective of the energy-redox axis: Lessons from a marine intertidal flatworm.Redox biology · 2016Article
- Lessons from nature: signalling cascades associated with vertebrate brain anoxic survival.Experimental physiology · 2016Article
- Comparative insights into mitochondrial adaptations to anoxia in brain.Neural regeneration research · 2016Article
- Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles.Biology letters · 2016Article
- Decreases in mitochondrial reactive oxygen species initiate GABA(A) receptor-mediated electrical suppression in anoxia-tolerant turtle neurons.The Journal of physiology · 2015Article
- Evolution of the oxygen sensitivity of cytochrome c oxidase subunit 4.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Western painted turtle survives months without oxygen. A key adaptation is a coordinated reduction of cellular ATP production and utilization that may be signaled by changes in the concentrations of reactive oxygen species (ROS) and cyclic nucleotides (cAMP and cGMP). Little is known about the involvement of cyclic nucleotides in the turtle's metabolic arrest and ROS have not been previously measured in any facultative anaerobes. The present study was designed to measure changes in these second messengers in the anoxic turtle. ROS were measured in isolated turtle brain sheets during a 40-min normoxic to anoxic transition. Changes in cAMP and cGMP were determined in turtle brain, pectoralis muscle, heart and liver throughout 4 h of forced submergence at 20-22 degrees C. Turtle brain ROS production decreased 25% within 10 min of cyanide or N(2)-induced anoxia and returned to control levels upon reoxygenation. Inhibition of electron transfer from ubiquinol to complex III caused a smaller decrease in [ROS]. Conversely, inhibition of complex I increased [ROS] 15% above controls. In brain [cAMP] decreased 63%. In liver [cAMP] doubled after 2 h of anoxia before returning to control levels with prolonged anoxia. Conversely, skeletal muscle and heart [cAMP] remained unchanged; however, skeletal muscle [cGMP] became elevated sixfold after 4 h of submergence. In liver and heart [cGMP] rose 41 and 127%, respectively, after 2 h of anoxia. Brain [cGMP] did not change significantly during 4 h of submergence. We conclude that turtle brain ROS production occurs primarily between mitochondrial complexes I and III and decreases during anoxia. Also, cyclic nucleotide concentrations change in a manner suggestive of a role in metabolic suppression in the brain and a role in increasing liver glycogenolysis.
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