ArticleThe European physical journal. E, Soft matter2007
Impact of receptor-ligand distance on adhesion cluster stability.
Article in The European physical journal. E, Soft matter, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Elasticity-associated rebinding rate of molecular bonds between soft elastic media.Biophysical journal · 2022Article
- Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking.Journal of the Royal Society, Interface · 2022Article
- A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow.International journal of molecular sciences · 2020Article
- SNARE machinery is optimized for ultrafast fusion.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Enhanced Delta-Notch Lateral Inhibition Model Incorporating Intracellular Notch Heterogeneity and Tension-Dependent Rate of Delta-Notch Binding that Reproduces Sprouting Angiogenesis Patterns.Scientific reports · 2018Article
- A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion.Royal Society open science · 2016Article
- Contractile fibers and catch-bond clusters: a biological force sensor?Biophysical journal · 2013Article
- Effect of viscous drag on multiple receptor-ligand bonds rupture force.Colloids and surfaces. B, Biointerfaces · 2012Article
- Rupture of multiple receptor-ligand bonds: bimodal distribution of bond rupture force.The European physical journal. E, Soft matter · 2012Article
- A theoretical method to determine unstressed off-rate from multiple bond force spectroscopy.Colloids and surfaces. B, Biointerfaces · 2012Article
- Effect of loading conditions on the dissociation behaviour of catch bond clusters.Journal of the Royal Society, Interface · 2012Article
- Hidden multiple bond effects in dynamic force spectroscopy.Biophysical journal · 2012Article
- Probing mechanical principles of focal contacts in cell-matrix adhesion with a coupled stochastic-elastic modelling framework.Journal of the Royal Society, Interface · 2011Review
- Cell-biomaterial mechanical interaction in the framework of tissue engineering: insights, computational modeling and perspectives.International journal of molecular sciences · 2011Review
- Dynamical organization of the cytoskeletal cortex probed by micropipette aspiration.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.PloS one · 2010Article
- Lifetime and strength of periodic bond clusters between elastic media under inclined loading.Biophysical journal · 2009Article
- Key role of receptor density in colloid/cell specific interaction: a quantitative biomimetic study on giant vesicles.The European physical journal. E, Soft matterArticle
- Stability estimation for unsupervised clustering: A review.Wiley interdisciplinary reviews. Computational statisticsReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells in multicellular organisms adhere to the extracellular matrix through two-dimensional clusters spanning a size range from very few to thousands of adhesion bonds. For many common receptor-ligand systems, the ligands are tethered to a surface via polymeric spacers with finite binding range, thus adhesion cluster stability crucially depends on receptor-ligand distance. We introduce a one-step master equation which incorporates the effect of cooperative binding through a finite number of polymeric ligand tethers. We also derive Fokker-Planck and mean field equations as continuum limits of the master equation. Polymers are modeled either as harmonic springs or as worm-like chains. In both cases, we find bistability between bound and unbound states for intermediate values of receptor-ligand distance and calculate the corresponding switching times. For small cluster sizes, stochastic effects destabilize the clusters at large separation, as shown by a detailed analysis of the stochastic potential resulting from the Fokker-Planck equation.
Indexed as
Identifiers
17347787What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.