ReviewMicrobiology and molecular biology reviews : MMBR2007
Surprising arginine biosynthesis: a reappraisal of the enzymology and evolution of the pathway in microorganisms.
Review in Microbiology and molecular biology reviews : MMBR, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 125 citations in OpenAlex.
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- Low initial metabolite production enhances stability in syntrophic bacterial consortia.Communications biology · 2026Article
- Evolution of lysine and arginine biosynthesis revealed by substrate specificity of lysine biosynthetic enzymes in Thermus thermophilus.The FEBS journal · 2026Article
- The Potential Mechanisms ofDrug design, development and therapy · 2025Article
- L-arginine metabolism ameliorates age-related cognitive impairment by Amuc_1100-mediated gut homeostasis maintaining.Aging cell · 2024Article
- Causal effects of plasma metabolites on chronic kidney diseases and renal function: a bidirectional Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Causal impact of human blood metabolites and metabolic pathways on serum uric acid and gout: a mendelian randomization study.Frontiers in endocrinology · 2024Article
- A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson's disease.Fluids and barriers of the CNS · 2023Article
- Dissecting the Arginine and Lysine Biosynthetic Pathways and Their Relationship in Haloarchaeon Natrinema gari J7-2 via Endogenous CRISPR-Cas System-Based Genome Editing.Microbiology spectrum · 2023Article
- Characteristics of the Gut Microbiome and Serum Metabolome in Patients with Functional Constipation.Nutrients · 2023Article
- DosR's multifaceted role onFrontiers in cellular and infection microbiology · 2023Article
- Biogenic Amine Levels Markedly Increase in the Aqueous Humor of Individuals with Controlled Type 2 Diabetes.International journal of molecular sciences · 2022Article
- Arginine inhibition of the argininosuccinate lyases is conserved among three orders in cyanobacteria.Plant molecular biology · 2022Article
- AhrC Negatively Regulates Streptococcus mutans Arginine Biosynthesis.Microbiology spectrum · 2022Article
- Genomics-Based Reconstruction and Predictive Profiling of Amino Acid Biosynthesis in the Human Gut Microbiome.Microorganisms · 2022Article
- Modulation of Fecal Metabolites by Heat Stress and Diet, and Their Association with Inflammation and Leaky Gut Markers in Dairy Cows.Metabolites · 2022Article
- Untargeted Metabolomics on Skin Mucus Extract ofFoods (Basel, Switzerland) · 2021Article
- Aging-related markers in rat urine revealed by dynamic metabolic profiling using machine learning.Aging · 2021Article
- Climate and development modulate the metabolome and antioxidative system of date palm leaves.Journal of experimental botany · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major aspects of the pathway of de novo arginine biosynthesis via acetylated intermediates in microorganisms must be revised in light of recent enzymatic and genomic investigations. The enzyme N-acetylglutamate synthase (NAGS), which used to be considered responsible for the first committed step of the pathway, is present in a limited number of bacterial phyla only and is absent from Archaea. In many Bacteria, shorter proteins related to the Gcn5-related N-acetyltransferase family appear to acetylate l-glutamate; some are clearly similar to the C-terminal, acetyl-coenzyme A (CoA) binding domain of classical NAGS, while others are more distantly related. Short NAGSs can be single gene products, as in Mycobacterium spp. and Thermus spp., or fused to the enzyme catalyzing the last step of the pathway (argininosuccinase), as in members of the Alteromonas-Vibrio group. How these proteins bind glutamate remains to be determined. In some Bacteria, a bifunctional ornithine acetyltransferase (i.e., using both acetylornithine and acetyl-CoA as donors of the acetyl group) accounts for glutamate acetylation. In many Archaea, the enzyme responsible for glutamate acetylation remains elusive, but possible connections with a novel lysine biosynthetic pathway arose recently from genomic investigations. In some Proteobacteria (notably Xanthomonadaceae) and Bacteroidetes, the carbamoylation step of the pathway appears to involve N-acetylornithine or N-succinylornithine rather than ornithine. The product N-acetylcitrulline is deacetylated by an enzyme that is also involved in the provision of ornithine from acetylornithine; this is an important metabolic function, as ornithine itself can become essential as a source of other metabolites. This review insists on the biochemical and evolutionary implications of these findings.
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