ArticleThe Journal of physiology2007
Additive protective effects of the addition of lactic acid and adrenaline on excitability and force in isolated rat skeletal muscle depressed by elevated extracellular K+.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- A single oral glucose load decreases arterial plasma [KPhysiological reports · 2021Trial
- Lactic acidosis: implications for human exercise performance.European journal of applied physiology · 2025Review
- Fatiguing high-intensity intermittent exercise depresses maximal NaPflugers Archiv : European journal of physiology · 2025Article
- Durability of the moderate-to-heavy-intensity transition is related to the effects of prolonged exercise on severe-intensity performance.European journal of applied physiology · 2024Article
- Power output at the moderate-to-heavy intensity transition decreases in a non-linear fashion during prolonged exercise.European journal of applied physiology · 2024Article
- Lactate in contemporary biology: a phoenix risen.The Journal of physiology · 2022Article
- Muscle Glycogen Metabolism and High-Intensity Exercise Performance: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2021Review
- Re-Evaluating the Oxidative Phenotype: Can Endurance Exercise Save the Western World?Antioxidants (Basel, Switzerland) · 2021Review
- The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU.Journal of sport and health science · 2020Review
- Synchronization Modulation of Na/K Pumps Induced Membrane Potential Hyperpolarization in Both Physiological and Hyperkalemic Conditions.The Journal of membrane biology · 2019Article
- The use of the SLC16A1 gene as a potential marker to predict race performance in Arabian horses.BMC genetics · 2019Article
- Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis.The Journal of general physiology · 2019Article
- Lactate metabolism: historical context, prior misinterpretations, and current understanding.European journal of applied physiology · 2018Review
- The brain behaves as a muscle?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Limitations in intense exercise performance of athletes - effect of speed endurance training on ion handling and fatigue development.The Journal of physiology · 2017Review
- Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle.The Journal of general physiology · 2016Review
- Effect of Lactate Accumulation during Exercise-induced Muscle Fatigue on the Sensorimotor Cortex.Journal of physical therapy science · 2013Article
- Effects of high-frequency stimulation and doublets on dynamic contractions in rat soleus muscle exposed to normal and high extracellular [K(+)].Physiological reports · 2013Article
- Relationship between membrane Cl- conductance and contractile endurance in isolated rat muscles.The Journal of physiology · 2013Article
- Effects of acidification and increased extracellular potassium on dynamic muscle contractions in isolated rat muscles.The Journal of physiology · 2010Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During strenuous exercise, extracellular K(+) ([K(+)](o)) is increased, which potentially can reduce muscle excitability and force production. In addition, exercise leads to accumulation of lactate and H(+) and increased levels of circulating catecholamines. Individually, reduced pH and increased catecholamines have been shown to counteract the depressing effect of elevated K(+). This study examines (i) whether the effects of addition of lactic acid and adrenaline on the excitability of isolated muscles are caused by separate mechanisms and are additive and (ii) whether the effect of adding lactic acid or increasing CO(2) is related to a reduction of intra- or extracellular pH. Rat soleus muscles were incubated at a [K(+)](o) of 15 mM, which reduced tetanic force by 85%. Subsequent addition of 20 mM lactic acid or 10(-5) M adrenaline led to a small recovery of force, but when added together induced an almost complete force recovery. Compound action potentials showed that the force recovery was associated with recovery of muscle excitability. The improved excitability after addition of adrenaline was associated with increased Na(+)-K(+) pump activity resulting in hyperpolarization and an increase in the chemical Na(+) gradient. In contrast, addition of lactic acid had no effect on the membrane potential or the Na(+)-K(+) pump activity, but most likely increased excitability via a reduction in intracellular pH. It is concluded that the protective effects of acidosis and adrenaline on muscle excitability and force took place via different mechanisms and were additive. The results suggest that circulating catecholamines and development of acidosis during exercise may improve the tolerance of muscles to elevated [K(+)](o).
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