Evidence map›Paper›PMID 17346815›Full record

ReviewBiochimica et biophysica acta2007

5-HT1A receptor-mediated apoptosis: death by JNK?

Emanuel Meller

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Chronic isolation stress compromises JNK/c-Jun signaling in rat brain.Journal of neural transmission (Vienna, Austria : 1996) · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Emanuel MellerMillhauser Laboratories, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA. emanuel.meller@med.nyu.edu
New York University · US

Funding

5-HT1A RECEPTOR/G PROTEIN COUPLING AND ADAPTATIONR01MH060592 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MELLER, EMANUEL · 2000 to 2003
$1.2M
NIMH NIH HHS R01 MH060592
6 · The paper itself

Abstract

There is growing interest in the potential use of 5-HT(1A) receptor agonists as neuroprotective agents in stroke and traumatic brain injury. However, a new study using a recombinant 5-HT(1A) receptor cell line suggests that these agonists may promote as well as inhibit apoptotic responses. Because heterologously expressed receptors may couple promiscuously to inappropriate signal transduction pathways, the results should be interpreted with caution.

Indexed as

Receptor, Serotonin, 5-HT1AAnimalsApoptosisBrain InjuriesGene ExpressionHumansMAP Kinase Kinase 4Neuroprotective AgentsRecombinant ProteinsSerotonin Receptor AgonistsSignal TransductionStrokeMAP Kinase Kinase 4Neuroprotective AgentsReceptor, Serotonin, 5-HT1ARecombinant ProteinsSerotonin Receptor Agonists

Identifiers

PMID17346815
PMCPMC1950678
OpenAlexW2147997822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.