Trial reportPsychopharmacology2007
Effects of topiramate on cue-induced cigarette craving and the response to a smoked cigarette in briefly abstinent smokers.
Trial report in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Topiramate decreases the salience of motivationally relevant visual cues among smokers with alcohol use disorder.Alcoholism, clinical and experimental research · 2022Trial
- A Randomized Trial Evaluating Whether Topiramate Aids Smoking Cessation and Prevents Alcohol Relapse in Recovering Alcohol-Dependent Men.Alcoholism, clinical and experimental research · 2017Trial
- Perceived medication assignment during a placebo-controlled laboratory study of varenicline: temporal associations of treatment expectancies with smoking-related outcomes.Psychopharmacology · 2014Trial
- Topiramate for smoking cessation: a randomized, placebo-controlled pilot study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Trial
- Effects of divalproex on smoking cue reactivity and cessation outcomes among smokers achieving initial abstinence.Experimental and clinical psychopharmacology · 2012Trial
- Varenicline effects on craving, cue reactivity, and smoking reward.Psychopharmacology · 2011Trial
- Valproate treatment and cocaine cue reactivity in cocaine dependent individuals.Drug and alcohol dependence · 2009Trial
- Cue-reactivity targeted smoking cessation intervention in individuals with tobacco use disorder: a scoping review.Frontiers in psychiatry · 2023Article
- SUBSTANCE USE AND ADDICTION AFFECT MORE THAN THE BRAIN: THE PROMISE OF NEUROCARDIAC INTERVENTIONS.Current addiction reports · 2021Article
- Topiramate for smoking cessation: Systematic review and meta-analysis.Tobacco prevention & cessation · 2020Article
- Relationship of nicotine deprivation and indices of alcohol use behavior to implicit alcohol and cigarette approach cognitions in smokers.Addictive behaviors · 2017Article
- Topiramate increases the rewarding properties of cocaine in young-adult mice limiting its clinical usefulness.Psychopharmacology · 2016Article
- Magnitude and duration of cue-induced craving for marijuana in volunteers with cannabis use disorder.Drug and alcohol dependence · 2016Article
- Effect of oral THC pretreatment on marijuana cue-induced responses in cannabis dependent volunteers.Drug and alcohol dependence · 2015Article
- Glutamatergic transmission in drug reward: implications for drug addiction.Frontiers in neuroscience · 2015Review
- Glutamatergic medications for the treatment of drug and behavioral addictions.Pharmacology, biochemistry, and behavior · 2012Review
- Counterbalancing in smoking cue research: a critical analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2010Review
- Familial vulnerability to an unusual cognitive adverse effect of topiramate: Discussion of mechanisms.Indian journal of psychiatry · 2010Article
- Topiramate in the treatment of substance-related disorders: a critical review of the literature.The Journal of clinical psychiatry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleClinical studies have shown that topiramate, an anticonvulsant medication, may be effective as a treatment for smoking cessation. However, less is known about topiramate effects on nicotine withdrawal and craving and its interactions with a smoked cigarette.
objectivesThe objective of this study was to investigate the effects of topiramate treatment on abstinence-related nicotine withdrawal, cue-induced cigarette craving, and the acute effects of a smoked cigarette. MATERIALS AND
methodsFifteen female and 25 male cigarette smokers were randomly assigned to 9-day treatment with topiramate (final titration dose, 75 mg/day) or placebo. On the last day of treatment, after a 3-h smoke-free abstinence period, participants were evaluated for symptoms of nicotine withdrawal and then underwent cigarette and neutral cue reactivity testing. Thirty minutes after completing cue exposure testing, participants were then evaluated for the acute effects of a smoked cigarette. Cue reactivity and acute smoking measures included subjective ratings of cigarette craving and withdrawal and physiological measures of skin conductance and temperature, heart rate, and blood pressure. In addition, smoking topography was measured using a puff volume apparatus.
resultsTopiramate treatment enhanced subjective ratings of withdrawal after the 3-h abstinence period and reduced pre-cue skin conductance levels. Cigarette cue exposure resulted in a moderate increase in craving, which was unaffected by treatment. Topiramate treatment enhanced the rewarding effects of a smoked cigarette, even while participants smoked less per puff and achieved lower plasma nicotine levels.
conclusionResults suggest that topiramate enhances both nicotine withdrawal and reward. These findings question the utility of topiramate treatment for smoking cessation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.