ArticleLeukemia2007
Telomere length of cord blood-derived CD34(+) progenitors predicts erythroid proliferative potential.
Article in Leukemia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Myelosuppression in Patients Treated with the Telomerase Inhibitor Imetelstat Is Not Mediated through Activation of Toll-Like Receptors.International journal of molecular sciences · 2020Article
- Article
- KLF1 directly activates expression of the novel fetal globin repressorBlood advances · 2017Article
- New prospects for targeting telomerase beyond the telomere.Nature reviews. Cancer · 2016Review
- MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.Leukemia · 2016Article
- Key Immune Cell Cytokines Affects the Telomere Activity of Cord Blood Cells In vitro.Advanced pharmaceutical bulletin · 2016Article
- Placenta-based therapies for the treatment of epidermolysis bullosa.Cytotherapy · 2015Review
- Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.Leukemia · 2015Article
- Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice.PloS one · 2015Article
- Ex-vivo expansion of red blood cells: how real for transfusion in humans?Blood reviews · 2012Review
- Red blood cell size is inversely associated with leukocyte telomere length in a large multi-ethnic population.PloS one · 2012Article
- Cord blood stem cells for hematopoietic transplantation.Stem cell reviews and reports · 2011Review
- Regulation of circulating progenitor cells in left ventricular dysfunction.Circulation. Heart failure · 2010Article
- Strategies to enhance umbilical cord blood stem cell engraftment in adult patients.Expert review of hematology · 2010Review
- Humanized culture medium for clinical expansion of human erythroblasts.Cell transplantation · 2010Article
- Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.Oncogene · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive telomere shortening has been demonstrated in inherited and acquired blood disorders, including aplastic anemia and myelodysplastic syndromes. It is possible that replicative exhaustion, owing to critical telomere shortening in hematopoietic progenitor cells (HPCs), contributes to the development of cytopenias in these disorders. However to date, a direct link between the telomere length (TL) of human HPCs and their proliferative potential has not been demonstrated. In the present investigation, the TL and level of telomerase enzyme activity (TA) detected in cord blood (CB)-derived HPCs was found to predict erythroid expansion (P<0.01 and P=0.01 respectively). These results were corroborated by a correlation between proliferation of erythroid cells and telomere loss (P=0.01). In contrast, no correlations were found between initial TL, telomere loss or TA and the expansion of other myeloid lineage-committed cells. There was also no correlation between TL or TA and the number of clonogenic progenitors, including primitive progenitors derived from long-term culture. Our investigations revealed upregulation of telomerase to tumor cell levels in CD34- cells undergoing erythroid differentiation. Together, these results provide new insight into the regulation of TL and TA during myeloid cell expansion and demonstrate that TL is an important determinant of CB-derived erythroid cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.