ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- The Phosphorylation of Kv1.3: A Modulatory Mechanism for a Multifunctional Ion Channel.Cancers · 2023Review
- The anticonvulsant retigabine suppresses neuronal KScientific reports · 2016Article
- Redox and nitric oxide-mediated regulation of sensory neuron ion channel function.Antioxidants & redox signaling · 2015Review
- Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism.The Journal of membrane biology · 2013Article
- Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor.Science signaling · 2013Article
- Multifaceted modulation of K+ channels by protein-tyrosine phosphatase ε tunes neuronal excitability.The Journal of biological chemistry · 2012Article
- Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Stargazin-related protein γ₇ is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth.Journal of cell science · 2011Article
- Direct or indirect regulation of calcium-activated chloride channel by calcium.The Journal of membrane biology · 2011Article
- Depolarization increases phosphatidylinositol (PI) 4,5-bisphosphate level and KCNQ currents through PI 4-kinase mechanisms.The Journal of biological chemistry · 2010Article
- p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Genistein inhibits voltage-gated sodium currents in SCG neurons through protein tyrosine kinase-dependent and kinase-independent mechanisms.Pflugers Archiv : European journal of physiology · 2008Article
- NGF inhibits M/KCNQ currents and selectively alters neuronal excitability in subsets of sympathetic neurons depending on their M/KCNQ current background.The Journal of general physiology · 2008Article
- The C-terminus of Kv7 channels: a multifunctional module.The Journal of physiology · 2008Review
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6 authors at 1 institution in 1 country.
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Abstract
KCNQ2/3 currents are the molecular basis of the neuronal M currents that play a critical role in neuron excitability. Many neurotransmitters modulate M/KCNQ currents through their G-protein-coupled receptors. Membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation are two mechanisms that have been proposed for modulation of KCNQ2/3 currents. In this study, we studied regulation of KCNQ2/3 currents by the epidermal growth factor (EGF) receptor, a member of another family of membrane receptors, receptor tyrosine kinases. We demonstrate here that EGF induces biphasic inhibition of KCNQ2/3 currents in human embryonic kidney 293 cells and in rat superior cervical ganglia neurons, an initial fast inhibition and a later slow inhibition. Additional studies indicate that the early and late inhibitions resulted from PtdIns(4,5)P2 hydrolysis and tyrosine phosphorylation, respectively. We further demonstrate that these two processes are mutually dependent. This study indicates that EGF is a potent modulator of M/KCNQ currents and provides a new dimension to the understanding of the modulation of these channels.
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