ArticleJournal of virology2007
Fitness declines in Tobacco etch virus upon serial bottleneck transfers.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- The replicative fitness and virulence of potato virus Y evolve differently in pepper lines with different levels of resistance and tolerance.The Journal of general virology · 2026Article
- Accumulation Dynamics of Defective Genomes during Experimental Evolution of Two Betacoronaviruses.Viruses · 2024Article
- Extending the Host Range of Fusarium Poae Virus 1 fromViruses · 2022Article
- Article
- Why are viral genomes so fragile? The bottleneck hypothesis.PLoS computational biology · 2021Article
- Idiosyncratic epistasis creates universals in mutational effects and evolutionary trajectories.Nature ecology & evolution · 2020Article
- Article
- The Signatures of Natural Selection and Molecular Evolution in Fusarium graminearum Virus 1.Frontiers in microbiology · 2020Article
- Construction and characterization of an infectious cDNA clone of potato virus S developed from selected populations that survived genetic bottlenecks.Virology journal · 2019Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Viral Fitness Correlates with the Magnitude and Direction of the Perturbation Induced in the Host's Transcriptome: The Tobacco Etch Potyvirus-Tobacco Case Study.Molecular biology and evolution · 2018Article
- Negative Epistasis in Experimental RNA Fitness Landscapes.Journal of molecular evolution · 2017Review
- Molecular variation of tomato yellow leaf curl virus in the insect vector Bemisia tabaci.Scientific reports · 2017Article
- Estimating virus effective population size and selection without neutral markers.PLoS pathogens · 2017Article
- Strain-dependent mutational effects for Pepino mosaic virus in a natural host.BMC evolutionary biology · 2017Article
- Evolutionary ecology of virus emergence.Annals of the New York Academy of Sciences · 2017Review
- Genetic variation in fitness within a clonal population of a plant RNA virus.Virus evolution · 2016Article
- Phylogenetic and recombination analysis of Tobacco bushy top virus in China.Virology journal · 2015Article
- Experimental evolution of an RNA virus in cells with innate immunity defects.Virus evolution · 2015Article
- Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations.Scientific reports · 2014Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been well established that populations of RNA viruses transmitted throughout serial bottlenecks suffer from significant fitness declines as a consequence of the accumulation of deleterious mutations by the onset of Muller's ratchet. Bottlenecks are unavoidably linked to different steps of the infectious cycle of most plant RNA viruses, such as vector-mediated transmissions and systemic colonization of new leaves. Here we report evidence for fitness declines by the accumulation of deleterious mutations in the potyvirus Tobacco etch virus (TEV). TEV was inoculated into the nonsystemic host Chenopodium quinoa, and local lesions were isolated and used to initiate 20 independent mutation accumulation lineages. Weekly, a random lesion from each lineage was isolated and used to inoculate the next set of plants. At each transfer, the Malthusian growth rate was estimated. After 11 consecutive transfers, all lineages suffered significant fitness losses, and one even became extinct. The average rate of fitness decline was 5% per day. The average pattern of fitness decline was consistent with antagonistic epistasis between deleterious mutations, as postulated for antiredundant genomes. Temporal fitness fluctuations were not explained by random noise but reflected more complex underlying processes related to emergence and self-organization phenomena.
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