ArticleJournal of virology2007
In vivo fitness costs of different Gag CD8 T-cell escape mutant simian-human immunodeficiency viruses for macaques.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect.The Journal of experimental medicine · 2026Article
- Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.PLoS pathogens · 2023Article
- Genetically barcoded SIV reveals the emergence of escape mutations in multiple viral lineages during immune escape.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Antibody escape kinetics of equine infectious anemia virus infection of horses.Journal of virology · 2015Article
- Linking pig-tailed macaque major histocompatibility complex class I haplotypes and cytotoxic T lymphocyte escape mutations in simian immunodeficiency virus infection.Journal of virology · 2014Article
- The high cost of fidelity.AIDS research and human retroviruses · 2014Review
- Modeling the within-host dynamics of HIV infection.BMC biology · 2013Review
- Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques.Journal of virology · 2012Article
- An "escape clock" for estimating the turnover of SIV DNA in resting CD4⁺ T cells.PLoS pathogens · 2012Article
- Transcriptionally abundant major histocompatibility complex class I alleles are fundamental to nonhuman primate simian immunodeficiency virus-specific CD8+ T cell responses.Journal of virology · 2011Article
- Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.PLoS pathogens · 2011Article
- CTL Escape and Viral Fitness in HIV/SIV Infection.Frontiers in microbiology · 2011Article
- Article
- Balancing reversion of cytotoxic T-lymphocyte and neutralizing antibody escape mutations within human immunodeficiency virus type 1 Env upon transmission.Journal of virology · 2009Article
- HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC.PLoS pathogens · 2009Article
- Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.PLoS pathogens · 2009Article
- Dynamics of immune escape during HIV/SIV infection.PLoS computational biology · 2008Article
- Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.Journal of virology · 2008Article
- Transmission of simian immunodeficiency virus carrying multiple cytotoxic T-lymphocyte escape mutations with diminished replicative ability can result in AIDS progression in rhesus macaques.Journal of virology · 2008Article
- CD4+ target cell availability determines the dynamics of immune escape and reversion in vivo.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics of immune escape and reversion depend upon the efficiency of CD8 cytotoxic T lymphocytes (CTL) and the fitness cost of escape mutations. Escape kinetics of three simian immunodeficiency virus Gag CTL epitopes in pigtail macaques were variable; those of KP9 and AF9 were faster than those of KW9. Kinetics of reversion of escape mutant virus to wild type upon passage to naïve major histocompatibility complex-mismatched macaques also varied. Rapid reversion occurred at KP9, gradual biphasic reversion occurred at AF9, and escape mutant KW9 virus failed to revert. The fitness impact of these mutations is KP9 > AF9 > KW9. These data provide insights into the differential utility of CTL in controlling viremia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.