ArticleBiochemical and biophysical research communications2007
Oxidation of calmodulin alters activation and regulation of CaMKII.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Toxicogenomics of the Freshwater Oligochaete,International journal of molecular sciences · 2024Article
- Activity-dependent mitochondrial ROS signaling regulates recruitment of glutamate receptors to synapses.eLife · 2024Article
- Regulation of neuronal excitability by reactive oxygen species and calcium signaling: Insights into brain aging.Current research in neurobiology · 2021Review
- The calmodulin redox sensor controls myogenesis.PloS one · 2020Article
- Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism.Biochimie · 2019Article
- Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats.Frontiers in physiology · 2019Article
- Redox Signaling in Neurotransmission and Cognition During Aging.Antioxidants & redox signaling · 2018Review
- Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.Redox biology · 2018Article
- Uncovering the Signaling Pathway behind Extracellular Guanine-Induced Activation of NO System: New Perspectives in Memory-Related Disorders.Frontiers in pharmacology · 2018Article
- Redox regulation of the actin cytoskeleton and its role in the vascular system.Free radical biology & medicine · 2017Review
- Deciphering the Biophysical Effects of Oxidizing Sulfur-Containing Amino Acids in Interferon-beta-1a using MS and HDX-MS.Journal of the American Society for Mass Spectrometry · 2017Article
- Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling.Scientific reports · 2016Article
- Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Impact of methionine oxidation on calmodulin structural dynamics.Biochemical and biophysical research communications · 2015Article
- Article
- Methionine oxidation activates a transcription factor in response to oxidative stress.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Age-Induced Alterations in Hippocampal Function and Metabolism.Aging and disease · 2011Article
- Post-translational modifications differentially affect IgG1 conformation and receptor binding.Molecular & cellular proteomics : MCP · 2010Article
- Interplay between calcium and reactive oxygen/nitrogen species: an essential paradigm for vascular smooth muscle signaling.Antioxidants & redox signaling · 2010Review
- Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Increases in reactive oxygen species and mis-regulation of calcium homeostasis are associated with various physiological conditions and disease states including aging, ischemia, exposure to drugs of abuse, and neurodegenerative diseases. In aged animals, this is accompanied by a reduction in oxidative repair mechanisms resulting in increased methionine oxidation of the calcium signaling protein calmodulin in the brain. Here, we show that oxidation of calmodulin results in an inability to: (1) activate CaMKII; (2) support Thr(286) autophosphorylation of CaMKII; (3) prevent Thr(305/6) autophosphorylation of CaMKII; (4) support binding of CaMKII to the NR2B subunit of the NMDA receptor; and (5) compete with alpha-actinin for binding to CaMKII. Moreover, oxidized calmodulin does not efficiently bind calcium/calmodulin-dependent protein kinase II (CaMKII) in rat brain lysates or in vitro. These observations contrast from past experiments performed with oxidized calmodulin and the plasma membrane calcium ATPase, where oxidized calmodulin binds to, and partially activates the PMCA. When taken together, these data suggest that oxidative stress may perturb neuronal and cardiac function via a decreased ability of oxidized calmodulin to bind, activate, and regulate the interactions of CaMKII.
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Registered trials
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