ArticleBritish journal of cancer2007
MCM immunocytochemistry as a first line cervical screening test in developing countries: a prospective cohort study in a regional cancer centre in India.
Article in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Starting DNA Synthesis: Initiation Processes during the Replication of Chromosomal DNA in Humans.Genes · 2024Review
- The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.Current issues in molecular biology · 2021Article
- Role of tesmin expression in non-small cell lung cancer.Oncology letters · 2021Article
- Association of Biomarkers for Human Papillomavirus With Survival Among Adults With Barrett High-grade Dysplasia and Esophageal Adenocarcinoma.JAMA network open · 2020Article
- Article
- An interaction network driven approach for identifying biomarkers for progressing cervical intraepithelial neoplasia.Scientific reports · 2018Article
- The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.Frontiers in molecular biosciences · 2018Review
- Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma.Journal of Cancer · 2018Article
- Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy.Cancer management and research · 2018Article
- DNA Replication Licensing Proteins for Early Detection of Lung CancerAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Diagnostic value of MCM2 immunocytochemical staining in cervical lesions and its relationship with HPV infection.International journal of clinical and experimental pathology · 2015Article
- Replication proteins and human disease.Cold Spring Harbor perspectives in biology · 2014Review
- Minichromosome maintenance 7 protein is a reliable biological marker for human cervical progressive disease.Journal of gynecologic oncology · 2012Article
- Evaluation of MCM-2 expression in TMA cervical specimens.PloS one · 2012Article
- A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe.Cell division · 2010Article
- Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants.Plant physiology · 2009Article
- HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS.Expert opinion on medical diagnostics · 2008Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Cervical screening is not available for the majority of women in resource-poor countries. An important factor is a lack of skilled operators necessary for high-throughput assessment of the Papanicolaou (Pap) test currently in use. We compared the efficacy of immunocytochemistry for minichromosome maintenance (MCM) proteins vs standard Pap testing at detecting disease in 455 cervical smears processed in a typical Indian screening laboratory. Conventional (non-monolayer) smears were stained manually and then examined by a cytotechnologist and a cytopathologist. The MCM test was called positive when immunolabelled cells were identified as dyskaryotic by the Pap counterstain. The MCM test was read more quickly than the Pap test (approximately 2 vs 10 min) and there was 100% inter-observer agreement compared with 85% for Pap (P<0.0001). The MCM test detected 10 biopsy-proven cancers or pre-cancers that were not detected by Pap (P=0.002; P=0.016 excluding three cases where the Pap was deemed unsatisfactory on review). The cases in question included one recurrent squamous carcinoma and one adenocarcinoma in a screening patient who would have returned to 5 year recall. There were no false positive MCM test results. We propose that MCM immunocytochemistry has considerable advantages for cervical screening in developing countries like India.
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