ArticleJournal of cellular biochemistry2007
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death.
Article in Journal of cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death.Nature communications · 2025Article
- "Methyl jasmonate: bridging plant defense mechanisms and human therapeutics".Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.Brain and behavior · 2023Article
- Relevance of AIF/CypA Lethal Pathway in SH-SY5Y Cells Treated with Staurosporine.International journal of molecular sciences · 2021Article
- The Mitochondrial Proteome of Tumor Cells: A SnapShot on Methodological Approaches and New Biomarkers.Biology · 2020Review
- PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.Molecular cell · 2017Article
- Lutein inhibits the migration of retinal pigment epithelial cells via cytosolic and mitochondrial Akt pathways (lutein inhibits RPE cells migration).International journal of molecular sciences · 2014Article
- Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection.Mitochondrion · 2013Article
- Mitochondrial Ca(2+) and apoptosis.Cell calcium · 2012Review
- Selective modulation of subtype III IP₃R by Akt regulates ER Ca²⁺ release and apoptosis.Cell death & disease · 2012Article
- Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine.OncoTargets and therapy · 2012Article
- Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling.Journal of clinical biochemistry and nutrition · 2011Article
- Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models.Mitochondrion · 2009Review
- PI3K/Akt pathway activation attenuates the cytotoxic effect of methyl jasmonate toward sarcoma cells.Neoplasia (New York, N.Y.) · 2008Article
- Article
- Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury.American journal of physiology. Renal physiology · 2008Article
- Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells.NeuropharmacologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Akt is a serine/threonine protein kinase that plays a vital role in promoting cellular survival. Predominantly cytosolic, upon stimulation with growth-factors or stress, active Akt translocates into mitochondria, but the functions of Akt in mitochondria are not yet fully understood. Mitochondria play a central role in apoptotic pathways and given Akt's functions in the cytoplasm, Akt in mitochondria may help preserve mitochondrial integrity during cellular stress. To test if the translocation of Akt into mitochondria is neuroprotective, adenoviral vectors expressing a constitutively active Akt, Ad-HA-Akt (DD), and a constitutively active Akt with a mitochondrial targeting signal, Ad-Mito-HA-Akt (DD), were generated. Human SH-SY5Y neuroblastoma cells expressing the adenoviral constructs were treated with staurosporine to initiate intrinsic apoptotic cell death and several aspects of the mitochondrial apoptotic pathway were evaluated. Expression of active Akt targeted to mitochondria was found to be sufficient to significantly reduce staurosporine-induced activation of caspase-3 and caspase-9, the release of cytochrome c from mitochondria, and Bax oligomerization at mitochondria. These findings demonstrate that intramitochondrial active Akt results in efficient protection against apoptotic signaling.
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