ArticleThe Journal of cell biology1992
Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 71 citations in OpenAlex.
- The influence of simulated microgravity on the proteome ofNPJ microgravity · 2015Article
- The actinin family of actin cross-linking proteins - a genetic perspective.Cell & bioscience · 2015Article
- α-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- α-actinin is required for the proper assembly of Z-disk/focal-adhesion-like structures and for efficient locomotion in Caenorhabditis elegans.Journal of molecular biology · 2010Article
- Conserved genes act as modifiers of invertebrate SMN loss of function defects.PLoS genetics · 2010Article
- Phylogenetic analysis of gene structure and alternative splicing in alpha-actinins.Molecular biology and evolution · 2010Article
- The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.PloS one · 2010Article
- The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.Molecular biology of the cell · 2009Article
- Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines.The open neuroscience journal · 2009Article
- Nebulin regulates the assembly and lengths of the thin filaments in striated muscle.The Journal of cell biology · 2005Article
- Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation.The Journal of cell biology · 2003Article
- Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis.Molecular biology of the cell · 2001Article
- Fine mapping of the alpha-actinin binding site within cysteine-rich protein.The Biochemical journal · 2000Article
- CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin.The Journal of cell biology · 1997Article
- Assembly of body wall muscle and muscle cell attachment structures in Caenorhabditis elegans.The Journal of cell biology · 1994Article
- Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster.The Journal of cell biology · 1993Article
- The role of actin bundling proteins in the assembly of filopodia in epithelial cells.Cell adhesion & migrationReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated accumulation of alpha-actinin, the principal cross-linker of actin filaments, in four Drosophila fliA mutants. A single gene is variably spliced to generate one nonmuscle and two muscle isoforms whose primary sequence differences are confined to a peptide spanning the actin binding domain and first central repeat. In fliA3 the synthesis of an adult muscle-specific isoform is blocked in flight and leg muscles, while in fliA4 the synthesis of nonmuscle and both muscle-specific isoforms is severely reduced. Affected muscles are weak or paralyzed, and, in the case of fliA3, atrophic. Their myofibrils, while structurally irregular, are remarkably normal considering that they are nearly devoid of a major contractile protein. Also surprising is that no obvious nonmuscle cell abnormalities can be discerned despite the fact that both the fliA1- and fliA4-associated mutations perturb the nonmuscle isoform. Our observations suggest that alpha-actinin stabilizes and anchors thin filament arrays, rather than orchestrating their assembly, and further imply that alpha-actinin function is redundant in both muscle and nonmuscle cells.
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