ArticleThe Journal of cell biology1992
Remodeling the cell surface distribution of membrane proteins during the development of epithelial cell polarity.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 97 citations in OpenAlex.
- Regulation of Kv1.4 potassium channels by PKC and AMPK kinases.Channels (Austin, Tex.) · 2018Article
- Article
- Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface.PLoS pathogens · 2011Article
- Intercellular junction assembly, dynamics, and homeostasis.Cold Spring Harbor perspectives in biology · 2010Review
- Sec3-containing exocyst complex is required for desmosome assembly in mammalian epithelial cells.Molecular biology of the cell · 2010Article
- Epithelial phenotype and the RPE: is the answer blowing in the Wnt?Progress in retinal and eye research · 2008Review
- Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton.Experimental cell research · 2008Article
- The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.PloS one · 2008Article
- Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue.Journal of clinical pathology · 2001Article
- Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.Oncogene · 1999Article
- Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage.The Journal of cell biology · 1998Article
- Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein.The Journal of cell biology · 1998Article
- Apiconuclear organization of microtubules does not specify protein delivery from the trans-Golgi network to different membrane domains in polarized epithelial cells.Molecular biology of the cell · 1998Article
- The O-glycosylated stalk domain is required for apical sorting of neurotrophin receptors in polarized MDCK cells.The Journal of cell biology · 1997Article
- Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor.The Journal of cell biology · 1997Article
- The cellular basis of metastasis.World journal of urology · 1996Review
- Protein zero, a nervous system adhesion molecule, triggers epithelial reversion in host carcinoma cells.The Journal of cell biology · 1995Article
- Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture.The Journal of cell biology · 1995Article
- Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The development of polarized epithelial cells from unpolarized precursor cells follows induction of cell-cell contacts and requires resorting of proteins into different membrane domains. We show that in MDCK cells the distributions of two membrane proteins, Dg-1 and E-cadherin, become restricted to the basal-lateral membrane domain within 8 h of cell-cell contact. During this time, however, 60-80% of newly synthesized Dg-1 and E-cadherin is delivered directly to the forming apical membrane and then rapidly removed, while the remainder is delivered to the basal-lateral membrane and has a longer residence time. Direct delivery of greater than 95% of these proteins from the Golgi complex to the basal-lateral membrane occurs greater than 48 h later. In contrast, we show that two apical proteins are efficiently delivered and restricted to the apical cell surface within 2 h after cell-cell contact. These results provide insight into mechanisms involved in the development of epithelial cell surface polarity, and the establishment of protein sorting pathways in polarized cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.