Evidence map›Paper›PMID 17340202›Full record

ArticleJournal of autism and developmental disorders2008

Arousal modulation in females with fragile X or Turner syndrome.

Jane Roberts, Michèle M M Mazzocco, Melissa M Murphy, Rudolf Hoehn-Saric

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Autonomic Function in Fragile X Syndrome: A Systematic Review.Journal of intellectual disability research : JIDR · 2026
    Pooled it
  2. Social Communication in Young Children With Sex Chromosome Trisomy (XXY, XXX, XYY): A Study With Eye Tracking and Heart Rate Measures.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Article
  3. Article
  4. Article
  5. Emotion recognition and visual-scan paths in Fragile X syndrome.Journal of autism and developmental disorders · 2013
    Article
  6. Article
  7. Current Gaps in Understanding the Molecular Basis of FXTAS.Tremor and other hyperkinetic movements (New York, N.Y.) · 2012
    Article
  8. Autonomic regulation in fragile X syndrome.Developmental psychobiology · 2011
    Article
  9. Article
  10. Article
  11. Article
  12. Physiological correlates of social avoidance behavior in children and adolescents with fragile x syndrome.Journal of the American Academy of Child and Adolescent Psychiatry · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jane RobertsFrank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michèle M M Mazzocco
Melissa M Murphy
Rudolf Hoehn-Saric
Johns Hopkins Medicine · USKennedy Krieger Institute · USUniversity of North Carolina at Chapel Hill · US

Funding

UNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 1985 to 2012
$28.7M
COGNITIVE AND GENETIC CORRELATES OF EARLY MATH SKILLSR01HD034061 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MAZZOCCO, MICHELE M · 1997 to 2006
$2.1M
Attention, Memory, and Executive Function in Fragile XR01HD040602 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAILEY, DONALD B · 2001 to 2006
$1.6M
NEURODEVELOPMENTAL PATHWAYS TO LEARNING DISABILITIESP50NS035359 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI DENCKLA, MARTHA BRIDGE · 1996 to 2000
$1.0M
NICHD NIH HHS P30 HD003110NICHD NIH HHS P30-HD003110-38S1NICHD NIH HHS P30-HD40602-01NICHD NIH HHS R01 HD034061NICHD NIH HHS R01 HD040602NINDS NIH HHS P50 NS35359
6 · The paper itself

Abstract

The present study was carried out to examine physiological arousal modulation (heart activity and skin conductance, across baseline and cognitive tasks, in females with fragile X or Turner syndrome and a comparison group of females with neither syndrome. Relative to the comparison group, for whom a greater increase in skin conductance was associated with poor arithmetic performance and less risk taking behavior, females with fragile X displayed a minimal increase in heart activity that was nevertheless associated with poor performance on mental arithmetic. In contrast, no arousal-cognitive performance relationship emerged for the group with Turner syndrome. Taken together, our findings suggest that distinct profiles of arousal modulation might be associated with cognitive deficits in these syndrome populations.

Indexed as

Fragile X SyndromeTurner SyndromeAdolescentAdultArousalCognition DisordersFemaleGalvanic Skin ResponseHeart RateHumansNeuropsychological TestsPoint MutationSeverity of Illness Index

Identifiers

PMID17340202
PMCPMC2730938
OpenAlexW2103815959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.