ArticleCurrent genetics2007
Modeling the septation initiation network (SIN) in fission yeast cells.
Article in Current genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast.Frontiers in cell and developmental biology · 2022Article
- An agent-based model of the fission yeast cell cycle.Current genetics · 2019Article
- Mitotic-Spindle Organizing Protein MztA Mediates Septation Signaling by Suppressing the Regulatory Subunit of Protein Phosphatase 2A-ParA inFrontiers in microbiology · 2018Article
- An Extended, Boolean Model of the Septation Initiation Network in S.Pombe Provides Insights into Its Regulation.PloS one · 2015Article
- Measuring affinities of fission yeast spindle pole body proteins in live cells across the cell cycle.Biophysical journal · 2013Article
- Dynamics of SIN asymmetry establishment.PLoS computational biology · 2013Article
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- Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network.PLoS computational biology · 2012Article
- Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases.Systems and synthetic biology · 2011Article
- Open cascades as simple solutions to providing ultrasensitivity and adaptation in cellular signaling.Physical biology · 2011Article
- On the role of cell signaling models in cancer research.Cancer research · 2009Review
- Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation.Molecular systems biology · 2009Article
- Temporal organization of the cell cycle.Current biology : CB · 2008Review
- Adaptive dynamics with a single two-state protein.Journal of the Royal Society, Interface · 2008Article
- Progress towards understanding the mechanism of cytokinesis in fission yeast.Biochemical Society transactions · 2008Review
- A hidden feedback in signaling cascades is revealed.PLoS computational biology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinesis in fission yeast is controlled by a signal transduction pathway called the Septation Initiation Network (SIN). From a dynamical point of view the most interesting questions about the regulation of fission yeast cytokinesis are: how do wild type cells ensure that septation is initiated only once per cycle? Why does the control system stay in a continuously septating state in some mutant strains? And how is it that the SIN remains active when cytokinesis fails? To answer these questions we construct a simplified mathematical model of the SIN and graft this regulatory module onto our previous model of cyclin-dependent kinase (Cdk) dynamics in fission yeast cells. The SIN is both activated and inhibited by mitotic Cdk/cyclin complexes. As a consequence of this dual regulation, the SIN gets activated only once at the end of mitosis, when Cdk activity drops. The mathematical model describes the timing of septation not only in wild type cells but also in mutants where components of the SIN are knocked out. The model predicts phenotypes of some uncharacterized mutant cells and shows how a cytokinesis checkpoint can stop the cell cycle if septation fails.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.