ArticleEuropean biophysics journal : EBJ2007
Mechanical and structural properties of in vitro neurofilament hydrogels.
Article in European biophysics journal : EBJ, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Neurofilament Biophysics: From Structure to Biomechanics.Molecular biology of the cell · 2024Review
- Review
- Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach.Biomolecules · 2021Article
- A minimal-length approach unifies rigidity in underconstrained materials.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Strain-Stiffening in Dynamic Supramolecular Fiber Networks.Journal of the American Chemical Society · 2018Article
- Utilizing a Structural Mechanics Approach to Assess the Primary Effects of Injury Loads Onto the Axon and Its Components.Frontiers in neurology · 2018Article
- Strain Stiffening Hydrogels through Self-Assembly and Covalent Fixation of Semi-Flexible Fibers.Angewandte Chemie (International ed. in English) · 2017Article
- Phosphorylation-Induced Mechanical Regulation of Intrinsically Disordered Neurofilament Proteins.Biophysical journal · 2017Article
- Exacerbation of Charcot-Marie-Tooth type 2E neuropathy following traumatic nerve injury.Brain research · 2015Article
- Neurofilament proteins in axonal regeneration and neurodegenerative diseases.Neural regeneration research · 2012Review
- Elasticity in ionically cross-linked neurofilament networks.Biophysical journal · 2010Article
- Gel-expanded to gel-condensed transition in neurofilament networks revealed by direct force measurements.Nature materials · 2010Article
- MAP2-mediated in vitro interactions of brain microtubules and their modulation by cAMP.European biophysics journal : EBJ · 2009Article
- Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration.Molecular neurobiology · 2008Review
- Chapter 19: Mechanical response of cytoskeletal networks.Methods in cell biology · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurofilaments belong to the class of cytoskeletal intermediate filaments and are the predominant structural elements in axons. They are composed of a semiflexible backbone and highly charged anionic sidearms protruding from the surface of the filaments. Here, the rheology of in-vitro networks of neurofilaments purified from pig spinal cord was determined. The mechanical properties of these networks are qualitatively similar to other hydrogels of semiflexible polymers. The low-deformation storage modulus G'(omega) showed a concentration (c) dependence of G' approximately c (1.3) that is consistent with a model for semiflexible networks, but was also observed for polyelectrolyte brushes. A terminal relaxation was not observed in the frequency range investigated (0.007-5 Hz), supporting the notion that sidearms act as cross-links hindering slip between filaments on a time scale of many minutes. The mesh size distribution of the network was measured by analysis of Brownian motion of embedded beads. The concentration dependence of the mesh size follows the same power law behaviour as found for F-actin networks, but shows a significantly wider distribution attributable to the smaller persistence length of neurofilaments. The attractive interaction between filaments is increased by addition of Al(3+) ions resulting in a reduction of the linear response regime from strains bigger than 80% to less than 30%.
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