ArticlePlant cell reports2007
Arabidopsis thaliana plants expressing human beta-defensin-2 are more resistant to fungal attack: functional homology between plant and human defensins.
Article in Plant cell reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Heterologous Production of Antimicrobial Peptides: Notes to Consider.The protein journal · 2024Article
- Discovery of Transfer Factors in Plant-Derived Proteins and an In Vitro Assessment of Their Immunological Activities.Molecules (Basel, Switzerland) · 2023Article
- Expression of Human β-defensin 2 (hBD-2) in Pichia Pastoris and Investigation of Its Binding Efficiency with ACE-2.The protein journal · 2023Article
- Engineering Macromolecular Trafficking Into the Citrus Vasculature.Frontiers in plant science · 2022Article
- Plant defensins: types, mechanism of action and prospects of genetic engineering for enhanced disease resistance in plants.3 Biotech · 2019Review
- Utilization of plant-derived recombinant human β-defensins (hBD-1 and hBD-2) for averting salmonellosis.Transgenic research · 2015Article
- Antimicrobial peptides from fish.Pharmaceuticals (Basel, Switzerland) · 2014Article
- Overexpression of a defensin enhances resistance to a fruit-specific anthracnose fungus in pepper.PloS one · 2014Article
- Article
- Defense gene expression is potentiated in transgenic barley expressing antifungal peptide Metchnikowin throughout powdery mildew challenge.Journal of plant research · 2012Article
- Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens.Journal of experimental botany · 2009Article
- Transgenic tobacco and peanut plants expressing a mustard defensin show resistance to fungal pathogens.Plant cell reports · 2008Article
- Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity.BMC plant biology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human beta-defensin-2 (hBD-2) is a small antimicrobial peptide with potent activity against different Gram-negative bacteria and fungal/yeast species. Since human beta-defensins and plant defensins share structural homology, we set out to analyse whether there also exists a functional homology between these defensins of different eukaryotic kingdoms. To this end, we constructed a plant transformation vector harbouring the hBD-2 coding sequence, which we transformed to Arabidopsis thaliana plants, giving rise to A. thaliana plants indeed expressing hBD-2. Furthermore, we could demonstrate that this heterologously produced hBD-2 possesses antifungal activity in vitro. Finally, we could show that hBD-2 expressing A. thaliana plants are more resistant against the broad-spectrum fungal pathogen Botrytis cinerea as compared to untransformed A. thaliana plants, and that this resistance is correlated with the level of active hBD-2 produced in these transgenic plants. Hence, we demonstrated a functional homology, next to the already known structural homology, between defensins originating from different eukaryotic kingdoms. To our knowledge, this is the first time that this is specifically demonstrated for plant and mammalian defensins.
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