ArticleClinical rheumatology2007
Obesity is independently associated with impaired quality of life in patients with rheumatoid arthritis.
Article in Clinical rheumatology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Patient-level factors predictive of interstitial lung disease in rheumatoid arthritis: a systematic review.RMD open · 2023Pooled it
- A systematic review of the association of obesity with the outcomes of inflammatory rheumatic diseases.Singapore medical journal · 2019Pooled it
- Can Rheumatologists Predict Eventual Need for Orthopaedic Intervention in Patients with Rheumatoid Arthritis? Results of a Systematic Review and Analysis of Two UK Inception Cohorts.Current rheumatology reports · 2017Pooled it
- The steps to health randomized trial for arthritis: a self-directed exercise versus nutrition control program.American journal of preventive medicine · 2015Trial
- Examining Age-Adjusted Associations between BMI and Comorbidities in Mongolia: Cross-Sectional Prevalence.Healthcare (Basel, Switzerland) · 2024Article
- Predictors of quality of life, functional status, depression and fatigue in early arthritis: comparison between clinically suspect arthralgia, unclassified arthritis and rheumatoid arthritis.BMC musculoskeletal disorders · 2024Article
- Incidence of collagen-induced arthritis is elevated by a high-fat diet without influencing body weight in mice.RMD open · 2024Article
- Prevalence of Malnutrition and Associated Factors in Older Patients with Rheumatoid Arthritis: A Cross-Sectional Study.Nutrients · 2023Article
- Body mass index does not affect response of rituximab in patients with rheumatoid arthritis: results from the TURKBİO registry.Turkish journal of medical sciences · 2023Article
- Correlation between percentage of fat mass and level of disease activity in rheumatoid arthritis.SAGE open medicine · 2022Article
- Autoimmune Rheumatic Diseases and Vascular Function: The Concept of Autoimmune Atherosclerosis.Journal of clinical medicine · 2021Review
- Association between Malnutrition and Quality of Life in Elderly Patients with Rheumatoid Arthritis.Nutrients · 2021Observational
- Molecular Changes in the Adipose Tissue Induced by Rheumatoid Arthritis: Effects of Disease-Modifying Anti-Rheumatic Drugs.Frontiers in immunology · 2021Article
- Inflammation, obesity and rheumatic disease: common mechanistic links. A narrative review.Therapeutic advances in musculoskeletal disease · 2018Review
- A meta-analysis of the relationship between body mass index and risk of rheumatoid arthritis.EXCLI journal · 2018Article
- Joint-specific assessment of swelling and power Doppler in obese rheumatoid arthritis patients.BMC musculoskeletal disorders · 2017Article
- Obesity Associated With Active, but Preserved Joints in Rheumatoid Arthritis: Results From our National Registry.Archives of rheumatology · 2016Article
- Evaluation of Endothelial Cell Adhesion Molecules and Anti-C1q Antibody in Discriminating between Active and Non-Active Systemic Lupus Erythematosus.The Malaysian journal of medical sciences : MJMS · 2016Article
- Impact of Bariatric Surgery on Patients With Rheumatoid Arthritis.Arthritis care & research · 2015Observational
- Future perspectives of Smartphone applications for rheumatic diseases self-management.Rheumatology international · 2015Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a modifiable major cause of morbidity and mortality in the general population, but little is known about the association of obesity and quality of life in patients with rheumatoid arthritis (RA). Thus, we set out a study to test the hypothesis that obesity is independently associated with lower quality of life in patients with RA. Three hundred and fifty nine patients with RA underwent an interview, physical exam, and all clinical charts were reviewed. Based on body mass index (BMI), patients were classified as normal (BMI < 25 kg/m(2)), overweight (BMI = 25-29.9 kg/m(2)), and obese (BMI > or = 30 kg/m(2)). Quality of life was quantified with the Medical Outcomes Study Short Form 36 (SF-36). Data obtained included demographic variables, extra-articular disease, comorbidities, presence of X-ray erosions, rheumatoid factor, and depression. The association between obesity and quality of life was examined with the use of multiple lineal regression models. One hundred and seventy-two patients (47.9%) had normal BMI, 126 (35.1%) were overweight, and 61 patients (17%) were obese. Obese patients had lower quality of life (30.8 +/- 18.1) than overweight patients (43.3 +/- 20.1) and patients with normal weight (43.8 +/- 22.2), P < 0.001. The association between obesity and impaired quality of life was confirmed with a linear regression model (Coef = -12.9, P < 0.001) and remained significant after adjustment for age, sex, disease activity, extra-articular disease, comorbidities, X-ray erosions, presence of rheumatoid factor, depression, education, and disease duration (Coef = -5.3, P = 0.039). In conclusion, obesity is independently associated with the impaired quality of life in patients with rheumatoid arthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.