ArticleJournal of immunology (Baltimore, Md. : 1950)2007
Induction of protective immunity to Listeria monocytogenes in neonates.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice.EMBO reports · 2023Article
- Neonatal Immune Responses to Respiratory Viruses.Frontiers in immunology · 2022Review
- T cells in the brain enhance neonatal mortality during peripheral LCMV infection.PLoS pathogens · 2021Article
- Neonatal T Cells: A Reinterpretation.Annual review of immunology · 2020Review
- Dissecting the defects in the neonatal CD8Journal of leukocyte biology · 2019Review
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- Brucella Peptide Cross-Reactive Major Histocompatibility Complex Class I Presentation Activates SIINFEKL-Specific T Cell Receptor-Expressing T Cells.Infection and immunity · 2018Article
- Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses.PloS one · 2018Article
- A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression.PloS one · 2018Article
- GNP-GAPDHOncotarget · 2017Article
- A Promising Listeria-Vectored Vaccine Induces Th1-Type Immune Responses and Confers Protection Against Tuberculosis.Frontiers in cellular and infection microbiology · 2017Article
- IL-12p40/IL-10 Producing preCD8α/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection.PLoS pathogens · 2016Article
- Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Rapid CD8Frontiers in pediatrics · 2016Article
- Article
- Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation.Allergy, asthma & immunology research · 2014Article
- Topical CpG adjuvantation of a protein-based vaccine induces protective immunity to Listeria monocytogenes.Clinical and vaccine immunology : CVI · 2014Article
- Is Infant Immunity Actively Suppressed or Immature?Virology : research and treatment · 2014Article
- Listeria monocytogenes: a promising vehicle for neonatal vaccination.Human vaccines & immunotherapeutics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Neonates suffer unduly from infections and also respond suboptimally to most commonly used vaccines. However, a CD8 T cell response can be elicited in neonates if the Ag is introduced into the cytoplasm of APCs. Listeria monocytogenes (Lm) targets the cytoplasm of APC and is a strong CD8 and CD4 Th1-promoting vaccine vehicle in adult mice. We hypothesized that an attenuated strain of Lm would be safe and induce long-lasting protective immunity, even in neonates. We found that neonatal mice immunized only once with the attenuated strain DeltaactA-Lm developed robust primary and secondary CD8 and CD4 Th1 responses and were fully protected from lethal challenge with virulent wild-type Lm without the need for a booster immunization. Furthermore, DeltaactA-Lm expressing a heterologous recombinant Ag induced a strong CD8 and Th1 memory response to that Ag. Based on these data, we propose that DeltaactA-Lm or derivatives thereof might serve as a vaccine vehicle for neonatal immunization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.