ArticleThe Journal of cell biology2007
Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- The Drosophila larval salivary gland, a simple and elegant model system to understand secretory organ development and function.Current opinion in insect science · 2026Review
- Arc controls organ architecture through modulation of Crb and MyoII.The Journal of cell biology · 2025Article
- Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone.Insects · 2023Review
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- Secrets of secretion-How studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying secretory organ form and function.Current topics in developmental biology · 2021Article
- Ecdysone controlled cell and tissue deletion.Cell death and differentiation · 2020Review
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- Hox targets and cellular functions.Scientifica · 2013Article
- Identification, expression and target gene analyses of Micrornas in Spodoptera litura.PloS one · 2012Article
- Fork head transcription factor is required for ovarian mature in the brown planthopper, Nilaparvata lugens (Stål).BMC molecular biology · 2011Article
- Steroid-triggered, cell-autonomous death of a Drosophila motoneuron during metamorphosis.Neural development · 2011Article
- Article
- Article
- Staying alive: dalmation mediated blocking of apoptosis is essential for tissue maintenance.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Steroid hormone control of cell death and cell survival: molecular insights using RNAi.PLoS genetics · 2009Article
- Genetic control of programmed cell death during animal development.Annual review of genetics · 2009Review
- Signalling pathways involved in adult heart formation revealed by gene expression profiling in Drosophila.PLoS genetics · 2007Article
- Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death.The Journal of cell biology · 2007Article
- To die or not to die--a role for Fork head.The Journal of cell biology · 2007Article
- Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize.Wiley interdisciplinary reviews. Developmental biologyReview
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3 authors at 1 institution in 1 country.
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Abstract
Cell death during Drosophila melanogaster metamorphosis is controlled by the steroid hormone 20-hydroxyecdysone (20E). Elements of the signaling pathway that triggers death are known, but it is not known why some tissues, and not others, die in response to a particular hormone pulse. We found that loss of the tissue-specific transcription factor Fork head (Fkh) is both required and sufficient to specify a death response to 20E in the larval salivary glands. Loss of fkh itself is a steroid-controlled event that is mediated by the 20E-induced BR-C gene, and that renders the key death regulators hid and reaper hormone responsive. These results implicate the D. melanogaster FOXA orthologue Fkh with a novel function as a competence factor for steroid-controlled cell death. They explain how a specific tissue is singled out for death, and why this tissue survives earlier hormone pulses. More generally, they suggest that cell identity factors like Fkh play a pivotal role in the normal control of developmental cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.