ArticleGenetics2007
Meiotic recombination in Drosophila Msh6 mutants yields discontinuous gene conversion tracts.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Review
- Article
- The role of Drosophila mismatch repair in suppressing recombination between diverged sequences.Scientific reports · 2015Article
- Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics.Nature genetics · 2014Article
- Eliminating both canonical and short-patch mismatch repair in Drosophila melanogaster suggests a new meiotic recombination model.PLoS genetics · 2014Article
- Removal of N-6-methyladenine by the nucleotide excision repair pathway triggers the repair of mismatches in yeast gap-repair intermediates.DNA repair · 2013Article
- Variation in meiotic recombination frequencies between allelic transgenes inserted at different sites in the Drosophila melanogaster genome.G3 (Bethesda, Md.) · 2013Article
- Article
- A Whole-Chromosome Analysis of Meiotic Recombination in Drosophila melanogaster.G3 (Bethesda, Md.) · 2012Article
- Zinc finger binding motifs do not explain recombination rate variation within or between species of Drosophila.PloS one · 2012Article
- Genome-wide analysis of heteroduplex DNA in mismatch repair-deficient yeast cells reveals novel properties of meiotic recombination pathways.PLoS genetics · 2011Article
- Gorgeous mosaic of mitochondrial genes created by horizontal transfer and gene conversion.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Discontinuity and limited linkage in the homologous recombination system of a hyperthermophilic archaeon.Journal of bacteriology · 2010Article
- Article
- Completion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1.Cell and tissue research · 2008Article
- Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2.Molecular and cellular biology · 2007Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination intermediates. Heterologies in hDNA are usually repaired prior to the recovery of recombination products, thereby obscuring information about the arrangement of hDNA. To examine hDNA in meiotic recombination in Drosophila melanogaster, we sought to block hDNA repair by conducting recombination assays in a mutant defective in mismatch repair (MMR). We generated mutations in the MMR gene Msh6 and analyzed recombination between highly polymorphic homologous chromosomes. We found that hDNA often goes unrepaired during meiotic recombination in an Msh6 mutant, leading to high levels of postmeiotic segregation; however, hDNA and gene conversion tracts are frequently discontinuous, with multiple transitions between gene conversion, restoration, and unrepaired hDNA. We suggest that these discontinuities reflect the activity of a short-patch repair system that operates when canonical MMR is defective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.