ReviewCurrent HIV/AIDS reports2007
Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy.
Review in Current HIV/AIDS reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 101 citations in OpenAlex.
- Immunologic markers as predictors of tuberculosis-associated immune reconstitution inflammatory syndrome in HIV and tuberculosis coinfected persons in Thailand.AIDS research and human retroviruses · 2009Trial
- People with HIV on antiretroviral therapy demonstrate robust humoral response to influenza vaccination.AIDS research and therapy · 2026Article
- Global HIV neurology: a comprehensive review.AIDS (London, England) · 2019Review
- TB-IRIS: Proteomic analysis of in vitro PBMC responses to Mycobacterium tuberculosis and response modulation by dexamethasone.Experimental and molecular pathology · 2017Article
- New insights into immune reconstitution inflammatory syndrome of the central nervous system.Current opinion in HIV and AIDS · 2014Review
- Periradicular lesions in HIV-infected patients attending the faculty of dentistry: clinical findings, socio-demographics status, habits and laboratory data - seeking an association.Clinics (Sao Paulo, Brazil) · 2014Article
- Article
- Central nervous system immune reconstitution inflammatory syndrome.Current infectious disease reports · 2013Article
- CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 1: overview and discussion of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome and cryptococcal-immune reconstitution inflammatory syndrome.AJNR. American journal of neuroradiology · 2013Review
- CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 2: discussion of neuro-immune reconstitution inflammatory syndrome with and without other pathogens.AJNR. American journal of neuroradiology · 2013Review
- LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients.PloS one · 2013Article
- Post-Kala-Azar Dermal Leishmaniasis: A Paradigm of Paradoxical Immune Reconstitution Syndrome in Non-HIV/AIDS Patients.Journal of tropical medicine · 2013Article
- [Immune reconstitution syndrome].Zeitschrift fur Rheumatologie · 2012Article
- Incidence, clinical spectrum, risk factors and impact of HIV-associated immune reconstitution inflammatory syndrome in South Africa.PloS one · 2012Article
- Triple class experience after initiation of combination antiretroviral treatment in Australia: survival and projections.Sexual health · 2011Article
- Article
- Timing of antiretroviral therapy for HIV in the setting of TB treatment.Clinical & developmental immunology · 2011Review
- Intractable chronic vulval ulceration presenting as immune reconstitution inflammatory syndrome in a treatment-failure patient: a case observation.Case reports in obstetrics and gynecology · 2011Article
- Early development of non-hodgkin lymphoma following initiation of newer class antiretroviral therapy among HIV-infected patients - implications for immune reconstitution.AIDS research and therapy · 2010Article
- Neurologic consequences of the immune reconstitution inflammatory syndrome (IRIS).Current neurology and neuroscience reports · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with HIV infection who were very immunodeficient before achieving a virologic response to antiretroviral therapy (ART) may experience various disorders of immune reconstitution. Immune restoration disease occurs in approximately 10% to 50% of patients and results from the restoration of a pathogen-specific immune response that causes immunopathology and presents as tissue inflammation or cellular proliferative disease. Opportunistic infections occur in no more than 5% of patients, but approximately one half of these patients have higher than expected CD4 T-cell counts and appear to have residual immune dysfunction. Autoimmune disease may arise because the reconstituted immune system confers an increased susceptibility to immune dysregulation but there may be different mechanisms because Graves' disease presents after a median time of about 2 years of ART whereas systemic lupus erythematosus presents earlier. Persistent CD4 T-cell deficiency (< 500/microL) affects up to 60% of patients and appears to reflect depletion of the naïve T-cell pool that results from low production and/or increased turnover of cells.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.