Evidence map›Paper›PMID 17337787›Full record

ReviewImmunologic research2006

Understanding and exploiting dendritic cells in human immunodeficiency virus infection using the nonhuman primate model.

Simon M Barratt-Boyes, Kevin N Brown, Nada Melhem, Adam C Soloff, Sherrianne M Gleason

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Dendritic cells as therapeutic targets in neuroinflammation.Cellular and molecular life sciences : CMLS · 2016
    Review
  4. Review
  5. Myeloid dendritic cells in HIV-1 infection.Current opinion in HIV and AIDS · 2011
    Review
  6. Article
  7. Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2010
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Simon M Barratt-BoyesDepartment of Infectious Diseases, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. smbb@pitt.edu
Kevin N Brown
Nada Melhem
Adam C Soloff
Sherrianne M Gleason

Funding

MECHANISMS OF DENDRITIC CELL BASED TUMOR IMMUNIZATIONP01CA073743 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINN, OLIVERA J · 1998 to 2009
$12.3M
RHESUS MONKEY DENDRITIC CELLS FOR TRANSPLANT TOLERANCEU01AI051698 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2002 to 2011
$4.9M
Whole Autologous SIV Vaccine Using Dendritic CellsR01AI052052 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BARRATT-BOYES, SIMON M · 2002 to 2006
$1.8M
NCI NIH HHS CA73743NIAID NIH HHS AI51698NIAID NIH HHS AI52052NIAID NIH HHS AI55794
6 · The paper itself

Abstract

Dendritic cells (DC) are pivotal cells in the innate immune system. Recent interest in the role of DC in human immunodeficiency virus (HIV) pathogenesis has increased with the finding that both myeloid (mDC) and plasmacytoid DC (pDC) are lost from blood during infection, associated with progression to disease. DC are also being studied intensively for their capacity to stimulate robust virus-specific immunity as vaccines. Here we discuss our work in these contrasting fields of DC biology using the rhesus macaque nonhuman primate model. We focus on studies of DC dynamics in lymphoid tissues during pathogenic simian immunodeficiency virus (SIV) infection, DC trafficking in health and disease, DC-based vaccination and the use of autologous virus as antigen for stimulation of virus-specific T cells.

Indexed as

Disease Models, AnimalAIDS VaccinesAnimalsChemotaxis, LeukocyteDendritic CellsHIV InfectionsHumansMacaca mulattaSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAIDS Vaccines

Identifiers

PMID17337787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.