ReviewImmunologic research2006
Apoptosis and autoimmunity.
Review in Immunologic research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Infection as a potential trigger in glial fibrillary acidic protein astrocytopathy: a case report and review of immunotherapeutic strategies.BMC neurology · 2026Pooled it
- B cells, autoimmunity, and innate immunity in 22q11.2 deletion syndrome: a two-center study and review of the literature.Central-European journal of immunology · 2026Article
- Transient Regression of Breast Carcinoma After Diagnostic Biopsy and Tumor Heterogeneity: A Case Report.Cureus · 2024Article
- Lymphocyte apoptosis and its association with the inflammatory markers and disease severity in juvenile-onset systemic lupus erythematosus patients.Pediatric rheumatology online journal · 2024Article
- Case report: Revealing a special and rare autoimmune GFAP astrocytopathy in the spinal cord succeeding Neurobrucellosis infection.Frontiers in immunology · 2022Article
- In vitro modulatory effect of dehydroepiandrosterone sulfate on apoptosis and expression of apoptosis-related genes in patients with systemic lupus erythematosus.Journal of cellular physiology · 2019Article
- Autoantibodies associated with prenatal and childhood exposure to environmental chemicals in Faroese children.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Susceptibility to acute rheumatic fever based on differential expression of genes involved in cytotoxicity, chemotaxis, and apoptosis.Infection and immunity · 2014Article
- Complement activation in acetaminophen-induced liver injury in mice.The Journal of pharmacology and experimental therapeutics · 2012Article
- Modulatory function of invariant natural killer T cells in systemic lupus erythematosus.Clinical & developmental immunology · 2012Review
- Type I interferon and systemic lupus erythematosus.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011Review
- Spontaneous regression of malignant tumors: Importance of the immune system and other factors (Review).Oncology letters · 2010Article
- Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes.Journal of clinical immunology · 2010Article
- Influence of B cell antigen receptor expression level on pathways of B cell tolerance induction.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Corticosteroids for multiple sclerosis: I. Application for treating exacerbations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007Review
- The effects of iron deficiency on neutrophil/monocyte apoptosis in children.Cell proliferation · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cell death by apoptosis plays a significant and seemingly contradictory role in the development and pathogenesis of autoimmune diseases. Apoptosis is integral to the assembly and maintenance of a healthy, self-tolerant immune system. However, many of the molecular and cellular events specific to apoptosis generate a reservoir of self-antigens with the potential to initiate and possibly perpetuate autoimmune conditions. Recent findings that support this latter, more sinister role for apoptosis have shed light on a mystery that is common to many systemic autoimmune diseases, namely, why the majority of autoantibodies produced in patients with these diseases target proteins that are normally found inside the cell, often within the nucleus. This review will discuss how autoantigens are specifically altered during the apoptotic process, and how the complement system participates in recognizing and clearing these potentially immunogenic packages.
Indexed as
Identifiers
17337761What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.