ReviewArchives of disease in childhood. Fetal and neonatal edition2007
Optimum oxygen therapy in preterm babies.
Review in Archives of disease in childhood. Fetal and neonatal edition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- The SafeBoosC II randomized trial: treatment guided by near-infrared spectroscopy reduces cerebral hypoxia without changing early biomarkers of brain injury.Pediatric research · 2016Trial
- Target ranges of oxygen saturation in extremely preterm infants.The New England journal of medicine · 2010Trial
- Evolution of oxygen therapy in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- Initial Insights into the Ideal Oxygen Saturation Target for Postterm Corrected Age Infants with Bronchopulmonary Dysplasia.Annals of the American Thoracic Society · 2025Article
- High-Flow and Low-Flow Oxygen Delivery by Nasal Cannula Evaluated in Infant and Adult Airway Replicas.Respiratory care · 2024Article
- Value of brain tissue oxygen saturation in neonatal respiratory distress syndrome: a clinical study.European journal of translational myology · 2024Article
- A Novel CPAP Device With an Integrated Oxygen Concentrator for Low Resource Countries: In Vitro Validation and Usability Test in Field.IEEE open journal of engineering in medicine and biology · 2024Article
- Oxygen toxicity: cellular mechanisms in normobaric hyperoxia.Cell biology and toxicology · 2023Review
- Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization.Experimental eye research · 2022Article
- Disrupted establishment of anaerobe and facultative anaerobe balance in preterm infants with extrauterine growth restriction.Frontiers in pediatrics · 2022Article
- Treating Apnea of Prematurity.Cureus · 2022Review
- Can Erythropoietin Reduce Hypoxemic Neurological Damages in Neonates With Congenital Heart Defects?Frontiers in pharmacology · 2021Review
- Case control study of risk factors and ophthalmological outcomes of very low birth weight infants with Type 1 retinopathy of prematurity.Singapore medical journal · 2020Article
- Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia.Journal of lung, pulmonary & respiratory research · 2020Article
- Vascular and Neuronal Protection in the Developing Retina: Potential Therapeutic Targets for Retinopathy of Prematurity.International journal of molecular sciences · 2019Review
- When the Best of Intentions Leads to Bad Outcomes.Pain and therapy · 2019Article
- Bronchopulmonary Dysplasia: Crosstalk Between PPARγ, WNT/β-Catenin and TGF-β Pathways; The Potential Therapeutic Role of PPARγ Agonists.Frontiers in pediatrics · 2019Review
- A Review of Oxygen Physiology and Appropriate Management of Oxygen Levels in Premature Neonates.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2018Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxygen is the most commonly used therapy in neonatal nurseries as an integral part of respiratory support. The goal of oxygen therapy is to achieve adequate delivery of oxygen to the tissue without creating oxygen toxicity. Oxygen must have been given to newborn preterm babies more than any other medicinal product in the past 60 years. Despite this, we still know very little about how much oxygen these babies actually need, or how much oxygen is safe to give, especially in the first few weeks of life. Recent observational studies have raised concerns that giving oxygen to target the saturation at "physiological" levels in newborn preterm babies may do more harm than good, but to date, clinicians have not been able to resolve the uncertainties surrounding optimum oxygen therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.