ArticleEukaryotic cell2007
The MAD1 adhesin of Metarhizium anisopliae links adhesion with blastospore production and virulence to insects, and the MAD2 adhesin enables attachment to plants.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
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Who cites it
110 citing papers in PubMed, 329 citations in OpenAlex.
- MaGti1, a Gti1/Pac2 family protein, contributes to conidiation pattern shift in Metarhizium acridum.Pest management science · 2026Article
- Oral Exposure toInsects · 2026Article
- Toward Sustainable Management ofPlants (Basel, Switzerland) · 2026Review
- Endophytic entomopathogenic fungi: The next frontier in mycological biocontrol.World journal of microbiology & biotechnology · 2026Review
- Response of Fungal Communities to Anthropogenic Disturbances in a Tropical Forest.Plant-environment interactions (Hoboken, N.J.) · 2026Article
- Genome sequencing and functional annotation of Metarhizium anisopliae TNAU-MA-GDU: Insights into virulence mechanisms against Spodoptera frugiperda.Molecular biology reports · 2026Article
- Advances in the use of entomopathogenic fungi to control ixodid ticks.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026Review
- Development of Mycoinsecticides: Advances in Formulation, Regulatory Challenges and Market Trends for Entomopathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Biomass and Extracts of Metarhizium robertsii MT008 as Potential Biopesticides for Controlling the Fruit Fly Anastrepha obliqua.Neotropical entomology · 2025Article
- A mycovirus enhances fitness of an insect pathogenic fungus and potentially modulates virulence through interactions between viral and host proteins.PLoS pathogens · 2025Article
- Molecular Mechanisms of the Biological Control of Pine Wilt Disease Using Microorganisms.Microorganisms · 2025Review
- Entomopathogenic fungi: insights into recent understanding.World journal of microbiology & biotechnology · 2025Review
- A Review of Biological and Sustainable Management Approaches forVeterinary sciences · 2025Review
- Parasitism by Entomopathogenic Fungi and Insect Host Defense Strategies.Microorganisms · 2025Review
- Topical Infection of Cordyceps militaris in Silkworm Larvae Through the Cuticle has Lower Infectivity Compared to Beauveria bassiana and Metarhizium anisopliae.Current microbiology · 2024Article
- Beauveria bassiana native strains affect the reproductive index of Rhipicephalus microplus ticks.Experimental & applied acarology · 2024Article
- MaAzaR, a ZnJournal of fungi (Basel, Switzerland) · 2024Article
- Transfection of entomopathogenicProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cla4A, a Novel Regulator of Gene Expression Networks Required for Asexual and Insect-Pathogenic Lifecycles ofInternational journal of molecular sciences · 2024Article
- Fights on the surface prior to fungal invasion of insects.PLoS pathogens · 2024Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metarhizium anisopliae is a fungus of considerable metabolic and ecological versatility, being a potent insect pathogen that can also colonize plant roots. The mechanistic details of these interactions are unresolved. We provide evidence that M. anisopliae adheres to insects and plants using two different proteins, MAD1 and MAD2, that are differentially induced in insect hemolymph and plant root exudates, respectively, and produce regional localization of adhesive conidial surfaces. Expression of Mad1 in Saccharomyces cerevisiae allowed this yeast to adhere to insect cuticle. Expression of Mad2 caused yeast cells to adhere to a plant surface. Our study demonstrated that as well as allowing adhesion to insects, MAD1 at the surface of M. anisopliae conidia or blastospores is required to orientate the cytoskeleton and stimulate the expression of genes involved in the cell cycle. Consequently, the disruption of Mad1 in M. anisopliae delayed germination, suppressed blastospore formation, and greatly reduced virulence to caterpillars. The disruption of Mad2 blocked the adhesion of M. anisopliae to plant epidermis but had no effects on fungal differentiation and entomopathogenicity. Thus, regulation, localization, and specificity control the functional distinction between Mad1 and Mad2 and enable M. anisopliae cells to adapt their adhesive properties to different habitats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.