ArticleJournal of bacteriology2007
Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- High prevalence ofFrontiers in microbiology · 2023Article
- Positive Selection of Mutations in the Helicobacter pyloriInfection and immunity · 2022Article
- Whole-Genome-BasedFrontiers in microbiology · 2021Article
- Helicobacter pylori diversification during chronic infection within a single host generates sub-populations with distinct phenotypes.PLoS pathogens · 2020Article
- Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps.Nature communications · 2019Article
- A Biotin Biosynthesis Gene Restricted to Helicobacter.Scientific reports · 2016Article
- Analysis of a single Helicobacter pylori strain over a 10-year period in a primate model.International journal of medical microbiology : IJMM · 2015Article
- Pan-genome analysis of human gastric pathogen H. pylori: comparative genomics and pathogenomics approaches to identify regions associated with pathogenicity and prediction of potential core therapeutic targets.BioMed research international · 2015Article
- Overview of the phytomedicine approaches against Helicobacter pylori.World journal of gastroenterology · 2014Review
- Helicobacter pylori DprA alleviates restriction barrier for incoming DNA.Nucleic acids research · 2013Article
- Ethnicity association of Helicobacter pylori virulence genotype and metronidazole susceptibility.World journal of gastroenterology · 2013Article
- Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential.PLoS pathogens · 2012Article
- Comparative genomics of Helicobacter pylori strains of China associated with different clinical outcome.PloS one · 2012Article
- Microevolution of a zoonotic Helicobacter population colonizing the stomach of a human host before and after failed treatment.Genome biology and evolution · 2012Article
- Pathogenicity island cag, vacA and IS605 genotypes in Mexican strains of Helicobacter pylori associated with peptic ulcers.Annals of clinical microbiology and antimicrobials · 2011Article
- Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter-strain DNA recombination.Molecular microbiology · 2011Article
- Recombination and DNA repair in Helicobacter pylori.Annual review of microbiology · 2011Review
- DNA damage triggers genetic exchange in Helicobacter pylori.PLoS pathogens · 2010Article
- Surreptitious manipulation of the human host by Helicobacter pylori.Gut microbes · 2010Article
- Repeat-associated plasticity in the Helicobacter pylori RD gene family.Journal of bacteriology · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Genetic diversity of the human gastric pathogen Helicobacter pylori in an individual host has been observed; whether this diversity represents diversification of a founding strain or a mixed infection with distinct strain populations is not clear. To examine this issue, we analyzed multiple single-colony isolates from two to four separate stomach biopsies of eight adult and four pediatric patients from a high-incidence Mexican population. Eleven of the 12 patients contained isolates with identical random amplified polymorphic DNA, amplified fragment length polymorphism, and vacA allele molecular footprints, whereas a single adult patient had two distinct profiles. Comparative genomic hybridization using whole-genome microarrays (array CGH) revealed variation in 24 to 67 genes in isolates from patients with similar molecular footprints. The one patient with distinct profiles contained two strain populations differing at 113 gene loci, including the cag pathogenicity island virulence genes. The two strain populations in this single host had different spatial distributions in the stomach and exhibited very limited genetic exchange. The total genetic divergence and pairwise genetic divergence between isolates from adults and isolates from children were not statistically different. We also analyzed isolates obtained 15 and 90 days after experimental infection of humans and found no evidence of genetic divergence, indicating that transmission to a new host does not induce rapid genetic changes in the bacterial population in the human stomach. Our data suggest that humans are infected with a population of closely related strains that vary at a small number of gene loci, that this population of strains may already be present when an infection is acquired, and that even during superinfection genetic exchange among distinct strains is rare.
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