ArticleApplied and environmental microbiology2007
Characterization of extended-host-range pseudo-T-even bacteriophage Kpp95 isolated on Klebsiella pneumoniae.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
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- Phage Host Range Expansion Through Directed Evolution on Highly Phage-Resistant Strains ofInternational journal of molecular sciences · 2025Article
- Isolation and Characterization of Lytic Bacteriophages against Antibiotic-ResistantArchives of Razi Institute · 2025Article
- Two novel phages infectingFrontiers in microbiology · 2025Article
- Characterization of the novel cross-genus phage vB_SmaS_QH3 and evaluation of its antibacterial efficacy againstFrontiers in microbiology · 2025Article
- Genome sequence of theMicrobiology resource announcements · 2024Article
- Characterization and biocontrol efficacy of lytic phage (KPP-1) that infects multidrug resistant Klebsiella variicola.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Characterization of a Lytic Bacteriophage and Demonstration of Its Combined Lytic Effect with a K2 Depolymerase on the HypervirulentMicroorganisms · 2023Article
- Isolation, characterization, and genomic analysis of a novel bacteriophage MA9V-1 infectingFrontiers in microbiology · 2023Article
- Lytic potential of a filamentous bacteriophage isolated from sewage water in Tehran on clinical carbapenem-resistant strains.Iranian journal of microbiology · 2022Article
- Isolation and Characterisation of Bacteriophage Selective for KeyPharmaceuticals (Basel, Switzerland) · 2022Article
- The First Cbk-Like Phage InfectingFrontiers in microbiology · 2022Article
- Bacteriophage ecology in biological wastewater treatment systems.Applied microbiology and biotechnology · 2021Review
- Isolation and Characterization of a Novel Lytic Bacteriophage against the K2 Capsule-Expressing HypervirulentMicroorganisms · 2021Article
- Bacteriophages ofJournal of medical microbiology · 2020Review
- Antimicrobial Resistance and Molecular Characterization of Extended-Spectrum β-Lactamases of Escherichia coli and Klebsiella spp. Isolates from Urinary Tract Infections in Southern Brazil.Microbial drug resistance (Larchmont, N.Y.) · 2019Observational
- Isolation and characterization of the first phage infecting ecologically important marine bacteria Erythrobacter.Virology journal · 2017Article
- Isolation of Potential Phages against Multidrug-Resistant Bacterial Isolates: Promising Agents in the Rivers of Kathmandu, Nepal.BioMed research international · 2017Article
- Bacteriophage ϕMAM1, a viunalikevirus, is a broad-host-range, high-efficiency generalized transducer that infects environmental and clinical isolates of the enterobacterial genera Serratia and Kluyvera.Applied and environmental microbiology · 2014Article
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5 authors.
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Abstract
Kpp95, isolated on Klebsiella pneumoniae, is a bacteriophage with the morphology of T4-type phages and is capable of rapid lysis of host cells. Its double-stranded genomic DNA (ca. 175 kb, estimated by pulsed-field gel electrophoresis) can be cut only by restriction endonucleases with a cleavage site flanked either by A and T or by T, as tested, suggesting that it contains the modified derivative(s) of G and/or C. Over 26 protein bands were visualized upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the virion proteins. N-terminal sequencing indicated that the most abundant band (46 kDa) is the major coat protein (gp23) which has been cleaved from a signal peptide likely with a length similar to that of T4. Phylogenetic analyses based on the sequences of the central region (263 amino acid residues) of gp23 and the full length of gp18 and gp19 placed Kpp95 among the pseudo-T-even subgroup, most closely related to the coliphage JS98. In addition to being able to lyse many extended-spectrum beta-lactamase strains of K. pneumoniae, Kpp95 can lyse Klebsiella oxytoca, Enterobacter agglomerans, and Serratia marcescens cells. Thus, Kpp95 deserves further studies for development as a component of a therapeutic cocktail, owing to its high efficiencies of host lysis plus extended host range.
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