ArticleApplied and environmental microbiology2007
The alternative sigma factor sigma B and the virulence gene regulator PrfA both regulate transcription of Listeria monocytogenes internalins.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- How Long Do Microorganisms Survive and Persist in Food? A Systematic Review.Microorganisms · 2025Review
- Genomic and pathogenicity islands ofFrontiers in molecular biosciences · 2023Review
- Application of Whole Genome Sequencing to Aid in Deciphering the Persistence Potential ofMicroorganisms · 2021Review
- Biofilm-isolated Listeria monocytogenes exhibits reduced systemic dissemination at the early (12-24 h) stage of infection in a mouse model.NPJ biofilms and microbiomes · 2021Article
- Transcriptomic and Phenotypic Analyses of the Sigma B-Dependent Characteristics and the Synergism between Sigma B and Sigma L inMicroorganisms · 2020Article
- Characterisation ofHeliyon · 2020Article
- Dual-species biofilm of Listeria monocytogenes and Escherichia coli on stainless steel surface.World journal of microbiology & biotechnology · 2018Article
- Invasion of the Brain bymBio · 2018Article
- Home Alone: Elimination of All but One Alternative Sigma Factor inFrontiers in microbiology · 2017Article
- Genes Associated with Desiccation and Osmotic Stress in Listeria monocytogenes as Revealed by Insertional Mutagenesis.Applied and environmental microbiology · 2015Article
- Proteomic Differences between Listeria monocytogenes Isolates from Food and Clinical Environments.Pathogens (Basel, Switzerland) · 2014Article
- Contributions of σ(B) and PrfA to Listeria monocytogenes salt stress under food relevant conditions.International journal of food microbiology · 2014Article
- Regulatory network features in Listeria monocytogenes-changing the way we talk.Frontiers in cellular and infection microbiology · 2014Review
- Acid shock of Listeria monocytogenes at low environmental temperatures induces prfA, epithelial cell invasion, and lethality towards Caenorhabditis elegans.BMC genomics · 2013Article
- Divergence of the SigB regulon and pathogenesis of the Bacillus cereus sensu lato group.BMC genomics · 2012Article
- Toward a Systemic Understanding of Listeria monocytogenes Metabolism during Infection.Frontiers in microbiology · 2012Article
- Rapid, transient, and proportional activation of σ(B) in response to osmotic stress in Listeria monocytogenes.Applied and environmental microbiology · 2011Article
- Blue and red light modulates SigB-dependent gene transcription, swimming motility and invasiveness in Listeria monocytogenes.PloS one · 2011Article
- Transcriptomic and phenotypic analyses identify coregulated, overlapping regulons among PrfA, CtsR, HrcA, and the alternative sigma factors sigmaB, sigmaC, sigmaH, and sigmaL in Listeria monocytogenes.Applied and environmental microbiology · 2011Article
- Growth temperature-dependent contributions of response regulators, σB, PrfA, and motility factors to Listeria monocytogenes invasion of Caco-2 cells.Foodborne pathogens and disease · 2010Article
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3 authors.
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Abstract
Some Listeria monocytogenes internalins are recognized as contributing to invasion of mammalian tissue culture cells. While PrfA is well established as a positive regulator of L. monocytogenes virulence gene expression, the stress-responsive sigma(B) has been recognized only recently as contributing to expression of virulence genes, including some that encode internalins. To measure the relative contributions of PrfA and sigma(B) to internalin gene transcription, we used reverse transcription-PCR to quantify transcript levels for eight internalin genes (inlA, inlB, inlC, inlC2, inlD, inlE, inlF, and inlG) in L. monocytogenes 10403S and in isogenic Delta prfA, Delta sigB, and Delta sigB Delta prfA strains. Strains were grown under defined conditions to produce (i) active PrfA, (ii) active sigma(B) and active PrfA, (iii) inactive PrfA, and (iv) active sigma(B) and inactive PrfA. Under the conditions tested, sigma(B) and PrfA contributed differentially to the expression of the various internalins such that (i) both sigma(B) and PrfA contributed to inlA and inlB transcription, (ii) only PrfA contributed to inlC transcription, (iii) only sigma(B) contributed to inlC2 and inlD transcription, and (iv) neither sigma(B) nor PrfA contributed to inlF and inlG transcription. inlE transcript levels were undetectable. The important role for sigma(B) in regulating expression of L. monocytogenes internalins suggests that exposure of this organism to environmental stress conditions, such as those encountered in the gastrointestinal tract, may activate internalin transcription. Interplay between sigma(B) and PrfA also appears to be critical for regulating transcription of some virulence genes, including inlA, inlB, and prfA.
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