ArticleBioorganic & medicinal chemistry letters2007
Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents.
Article in Bioorganic & medicinal chemistry letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Advance of structural modification of nucleosides scaffold.European journal of medicinal chemistry · 2021Review
- Structural and functional insights into non-structural proteins of coronaviruses.Microbial pathogenesis · 2021Review
- Advances in developing small molecule SARS 3CLTetrahedron · 2021Review
- Role of heterocyclic compounds in SARS and SARS CoV-2 pandemic.Bioorganic chemistry · 2020Review
- Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review.RSC advances · 2020Review
- Structural basis for the development of SARS 3CL protease inhibitors from a peptide mimic to an aza-decaline scaffold.Biopolymers · 2016Article
- An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.Journal of medicinal chemistry · 2016Review
- The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing.Advances in virus research · 2016Review
- Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors.Bioorganic & medicinal chemistry · 2015Article
- SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets.Antiviral research · 2014Review
- Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors.Bioorganic & medicinal chemistry · 2014Article
- Biosynthesis of anti-HCV compounds using thermophilic microorganisms.Bioorganic & medicinal chemistry letters · 2012Article
- Synthesis and characterization of oligodeoxyribonucleotides containing a site-specifically incorporated N6-carboxymethyl-2'-deoxyadenosine or N4-carboxymethyl-2'-deoxycytidine.Nucleic acids research · 2010Article
- Severe acute respiratory syndrome (SARS).Infectious disease clinics of North America · 2010Review
- Deoxygenation of 5-Tetrahedron letters · 2008Article
- 5'-O-masked 2'-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents.Bioorganic & medicinal chemistry · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-SARS-CoV agents. Among these analogues, two compounds, namely, 1 and 11, exhibited promising anti-SARS-CoV activity that was comparable to those of mizoribine and ribavirin, which are known anti-SARS-CoV agents. Moreover, we observed several SAR trends such as the antiviral effects of the 6-chloropurine moiety, unprotected 5'-hydroxyl group and benzoylated 5'-hydroxyl group.
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