ReviewClinical and experimental immunology1992
Molecular heterogeneity of human IgA antibodies during an immune response.
Review in Clinical and experimental immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Subclass distribution of IgA antibodies in saliva and serum after immunization with Haemophilus influenzae type b conjugate vaccines.Clinical and experimental immunology · 1998Trial
- Structural promiscuity in the human circulatory IgA1 clonal repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neutralizing activity of a third dose of CoronaVac against Omicron subvariants within a 20-month follow-up study.Human vaccines & immunotherapeutics · 2023Article
- Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA.Frontiers in immunology · 2022Article
- Evaluation of Mucosal Humoral and Cellular Immune Responses to HIV in External Secretions and Mucosal Tissues.Current immunology reviews · 2019Article
- Detection of virus-specific polymeric immunoglobulin A in acute hepatitis A, C, E virus serum samples using novel chimeric secretory component.BMC research notes · 2018Article
- The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy.Frontiers in immunology · 2016Review
- Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination.Frontiers in immunology · 2012Article
- Methods for evaluation of humoral immune responses in human genital tract secretions.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Review
- Stone age diseases and modern AIDS.Virology journal · 2008Article
- Subclass distribution of natural salivary IgA antibodies against pneumococcal capsular polysaccharide of type 14 and pneumococcal surface adhesin A (PsaA) in children.Clinical and experimental immunology · 2006Article
- Mucosal immunity: overcoming the barrier for induction of proximal responses.Immunologic research · 2004Review
- Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils.The American journal of pathology · 2000Article
- Fecal antibodies to Cryptosporidium parvum in healthy volunteers.Infection and immunity · 2000Article
- Intestinal IgA: novel views on its function in the defence of the largest mucosal surface.Gut · 1999Article
- Increased IL-10 production by stimulated whole blood cultures in primary IgA nephropathy.Clinical and experimental immunology · 1998Article
- Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system.Immunologic research · 1997Review
- Total IgA and IgG in Sera of Patients With Different Primary Malignancies.Pathology oncology research : POR · 1996Article
- Ankylosing spondylitis, IgA, and transforming growth factors.Annals of the rheumatic diseases · 1995Review
- Pathogenesis of idiopathic IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 1993Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Human IgA occurs in multiple molecular forms (polymeric and monomeric) and two subclasses which show differential distribution between the mucosal and circulatory compartments of the immune system. However, the molecular form and subclass of specific IgA antibodies are influenced, especially during an immune response, by the type of antigen and duration of the response as well as by the route of exposure. These considerations question previously held notions that polymeric IgA and an increased representation of the IgA2 subclass among circulating antibodies or antibody-secreting cells signify their mucosal origin. Although the functional properties of different molecular forms and subclasses of IgA antibodies are incompletely understood, it appears that there is physiological benefit in the diversity of the IgA immune system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.