ArticleVirology2007
Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Occult hepatitis B virus infection among hepatitis B surface antigen negative vaccinated healthcare workers in East Gojjam zone hospitals.Scientific reports · 2026Article
- Sex-Dependent Regulation of Liver Fibrosis in Primary Sclerosing Cholangitis: The Role of miR-125b, Androgen Receptors, TGF-β, and Apelin Signalling.International journal of molecular sciences · 2025Article
- Secular Trends of Clinical Characteristics and Survival of Hepatocellular Carcinoma in Taiwan from 2011 to 2019.Viruses · 2022Article
- Pathogenicity and virulence of Hepatitis B virus.Virulence · 2022Review
- The Hepatitis B Virus Interactome: A Comprehensive Overview.Frontiers in microbiology · 2021Review
- Overexpression of the androgen receptor in human hepatoma cells and its effect on fatty acid metabolism.Oncology letters · 2017Article
- Androgen Receptor Could Be a Potential Therapeutic Target in Patients with Advanced Hepatocellular Carcinoma.Cancers · 2017Article
- Androgen receptor in hepatocarcinogenesis: Recent developments and perspectives.Oncology letters · 2015Article
- The androgen receptor as an emerging target in hepatocellular carcinoma.Journal of hepatocellular carcinoma · 2015Review
- Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers.World journal of gastroenterology · 2014Review
- Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver.Oncogene · 2014Review
- Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis.Endocrine-related cancer · 2014Review
- The DNA virus white spot syndrome virus uses an internal ribosome entry site for translation of the highly expressed nonstructural protein ICP35.Journal of virology · 2013Article
- Hepatitis B virus, a sex hormone-responsive virus.Gastroenterology · 2012Article
- Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.Hepatology (Baltimore, Md.) · 2012Article
- Enhancement of hepatitis B virus replication by androgen and its receptor in mice.Journal of virology · 2012Article
- The hepatitis B virus x protein inhibits thymine DNA glycosylase initiated base excision repair.PloS one · 2012Article
- FBI-1 functions as a novel AR co-repressor in prostate cancer cells.Cellular and molecular life sciences : CMLS · 2011Article
- Hepatitis C virus core protein augments androgen receptor-mediated signaling.Journal of virology · 2008Article
- Role of sex steroid receptors in pathobiology of hepatocellular carcinoma.World journal of gastroenterology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Hepatitis B virus (HBV) X protein (HBx) is a regulatory protein that is required for efficient replication of HBV in its natural host. In this report, we demonstrate by co-immunoprecipitation experiments that HBx can physically bind to the androgen receptor (AR), which is a nuclear hormone receptor that is expressed in many different tissues including the liver. This observation is further supported by confocal microscopy, which reveals that HBx can alter the subcellular localization of the AR both in the presence and in the absence of dihydrotestosterone (DHT). Further studies indicate that HBx can enhance the gene transactivation activity of AR by enhancing its DNA binding activity in a DHT-dependent manner. However, HBx does not remain associated with AR on the DNA. As AR can regulate the expression of a number of cellular genes, our results raise the possibility that HBV pathogenesis may be mediated in part via the interaction between HBx and AR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.