ArticleExperimental and molecular pathology2007
Neuroinflammatory response of the choroid plexus epithelium in fatal diabetic ketoacidosis.
Article in Experimental and molecular pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Circulating matrix metalloproteinases in children with diabetic ketoacidosis.Pediatric diabetes · 2017Trial
- Early expression of neuroinflammation in an untreated fatal case of diabetic ketoacidosis.Archives of endocrinology and metabolism · 2024Article
- Correlation between Neutrophil-to-Lymphocyte Ratio and Cerebral Edema in Children with Severe Diabetic Ketoacidosis.Biomedicines · 2023Article
- SGLT2 Inhibition by Dapagliflozin Attenuates Diabetic Ketoacidosis in Mice with Type-1 Diabetes.Cardiovascular drugs and therapy · 2022Article
- Brain injury in children with diabetic ketoacidosis: Review of the literature and a proposed pathophysiologic pathway for the development of cerebral edema.Pediatric diabetes · 2021Review
- Article
- Soluble Receptor for Glycation End-products Concentration Increases Following the Treatment of Severe Diabetic KetoacidosisJournal of clinical research in pediatric endocrinology · 2020Article
- Intracerebral matrix metalloproteinase 9 in fatal diabetic ketoacidosis.Experimental and molecular pathology · 2019Article
- Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica.Acta neuropathologica · 2017Article
- Complement and Humoral Adaptive Immunity in the Human Choroid Plexus: Roles for Stromal Concretions, Basement Membranes, and Epithelium.Journal of neuropathology and experimental neurology · 2016Article
- Autophagy in the brains of young patients with poorly controlled T1DM and fatal diabetic ketoacidosis.Experimental and molecular pathology · 2012Review
- Do β-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration?TheScientificWorldJournal · 2012Review
- Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis.Brain research · 2011Article
- Measles virus neurovirulence and host immunity.Future virology · 2011Article
- Brain endothelial cell-cell junctions: how to "open" the blood brain barrier.Current neuropharmacology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
A systemic inflammatory response (SIR) occurs prior to and during the treatment of severe diabetic ketoacidosis (DKA). IL-1beta, TNF-alpha and C5b-9 are components of SIR and have been speculated to be involved in the clinical brain edema (BE) of DKA. We studied IL-1beta, TNF-alpha, C5b-9, inducible nitric oxide (iNOS), ICAM-1, IL-10 and Hsp70 expression in the brains of two patients who died as the result of clinical BE during the treatment of DKA. IL-1beta was strongly expressed in the choroid plexus epithelium (CPE) and ependyma, and to a lesser extent in the hippocampus, caudate, white matter radiation of the pons, molecular layer of the cerebellum and neurons of the cortical gray matter. TNF-alpha was expressed to a lesser extent than IL-1beta, and only in the CP. C5b-9, previously shown to be deposited on neurons and oligodendrocytes, was found on CPE and ependymal cells. iNOS and ICAM-1 had increased expression in the CPE and ependyma. Hsp70 and IL-10 were also expressed in the CPE of the case with the shorter duration of treatment. Our data demonstrate the presence of a multifaceted neuroinflammatory cytotoxic insult of the CPE, which may play a role in the pathophysiology of the fatal brain edema of DKA.
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