ArticleBMC developmental biology2007
Mechanism of G1 arrest in the Drosophila eye imaginal disc.
Article in BMC developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Cell Cycle Regulation by NF-YC inInternational journal of molecular sciences · 2023Article
- Coordination between cell proliferation and apoptosis after DNA damage in Drosophila.Cell death and differentiation · 2022Article
- Role of Serotonin Transporter in Eye Development ofInternational journal of molecular sciences · 2020Article
- Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye.Evolution & development · 2019Article
- Tissue-Specific Upregulation of Drosophila Insulin Receptor (InR) Mitigates Poly(Q)-Mediated Neurotoxicity by Restoration of Cellular Transcription Machinery.Molecular neurobiology · 2019Article
- Article
- Detecting proliferation of adult hemocytes inWellcome open research · 2018Article
- Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in theDevelopment (Cambridge, England) · 2017Article
- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis.PLoS genetics · 2016Article
- Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication.Development (Cambridge, England) · 2015Article
- Eye selector logic for a coordinated cell cycle exit.PLoS genetics · 2015Article
- Article
- Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals.Development (Cambridge, England) · 2013Article
- Article
- My what big eyes you have: how the Drosophila retina grows.Developmental neurobiology · 2011Review
- Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye.Development (Cambridge, England) · 2011Article
- Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Cell cycle arrest by a gradient of Dpp signaling during Drosophila eye development.BMC developmental biology · 2010Article
- The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs.Genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundMost differentiating cells are arrested in G1-phase of the cell cycle and this proliferative quiescence appears important to allow differentiation programmes to be executed. An example occurs in the Drosophila eye imaginal disc, where all cells are synchronized and arrested in G1 phase prior to making a fate choice either to initiate the first round of photoreceptor differentiation or to re-enter one terminal mitosis.
resultsWe have analysed the mechanism of this temporally regulated G1-phase in order to develop an integrated model of this proliferative regulation. We find that an overlapping set of cell cycle inhibitors combine to form an efficient barrier to cell cycle progression. This barrier depends on both the primary secreted signals that drive retinal development, Dpp and Hh. Each of these has distinct, as well as partially overlapping functions, in ensuring that Cyclin E and dE2F1 are kept in check. Additionally, inhibition of Cyclin A by Roughex is essential, and this regulation is independent of Dpp and Hh.
conclusionOne implication of these results is to further support the idea that Cyclin A has important functions in S-phase entry as well as in mitosis. The unexpectedly complex network of regulation may reflect the importance of cells being uniformly ready to respond to the inductive signals that coordinate retinal differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.