ArticleEuropean journal of nuclear medicine and molecular imaging2007
Assessment of intra- and interobserver reproducibility of rest and cold pressor test-stimulated myocardial blood flow with (13)N-ammonia and PET.
Article in European journal of nuclear medicine and molecular imaging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Trial
- Feasibility and operator variability of myocardial blood flow and reserve measurements with ⁹⁹mTc-sestamibi quantitative dynamic SPECT/CT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Prevalence of impaired flow-mediated epicardial vasodilation among different types of coronary flow regulation.The international journal of cardiovascular imaging · 2026Article
- The impact of fast vs. slow rubidium-82 infusion profile on precision and accuracy of PET myocardial blood flow perfusion metrics using a 1-tissue compartment model.European heart journal. Imaging methods and practice · 2025Article
- Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Effect of short-term smoking & L-arginine on coronary endothelial function assessed by cardiac magnetic resonance cold pressor testing: a pilot study.BMC cardiovascular disorders · 2021Article
- Relative disagreement among different software packages in PET-flow quantitation: An appeal for consistency.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Motion correction to enhance absolute myocardial blood flow quantitation by PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Accuracy of Myocardial Blood Flow Estimation From Dynamic Contrast-Enhanced Cardiac CT Compared With PET.Circulation. Cardiovascular imaging · 2019Article
- 15-O-water myocardial flow reserve PET and CT angiography by full hybrid PET/CT as a potential alternative to invasive angiography.The international journal of cardiovascular imaging · 2018Article
- Fully automated, inline quantification of myocardial blood flow with cardiovascular magnetic resonance: repeatability of measurements in healthy subjects.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Article
- Reporting myocardial flow reserve with PET. Ready or not, here it is! But walk before you fly!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Coronary microvascular dysfunction in women with nonobstructive ischemic heart disease as assessed by positron emission tomography.Cardiovascular diagnosis and therapy · 2017Review
- Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements withComputational and mathematical methods in medicine · 2017Article
- Myocardial blood flow: Putting it into clinical perspective.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina.European journal of nuclear medicine and molecular imaging · 2016Article
- Precision and accuracy of clinical quantification of myocardial blood flow by dynamic PET: A technical perspective.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Time-efficient myocardial contrast partition coefficient measurement from early enhancement with magnetic resonance imaging.PloS one · 2014Article
- PET tracers and techniques for measuring myocardial blood flow in patients with coronary artery disease.Journal of biomedical research · 2013Review
- Blood flow, flow reserve, and glucose utilization in viable and nonviable myocardium in patients with ischemic cardiomyopathy.European journal of nuclear medicine and molecular imaging · 2013Article
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7 authors.
Funding
Abstract
purposeWe investigated the intraobserver reproducibility of myocardial blood flow (MBF) measurements with PET at rest and during cold pressor test (CPT), and the interobserver agreement.
methodsTwenty normal volunteers were studied. Using (13)N-ammonia, MBF was measured at rest and during CPT and measurement was repeated in a 1-day session (short-term reproducibility; SR). After a follow-up of 2 weeks, MBF was measured again at rest and during CPT and compared with the initial baseline measurement (long-term reproducibility; LR). In addition, adenosine-induced hyperemic MBF increases were assessed.
resultsAssessment of the SR did not show a significant absolute difference in MBF at rest, MBF during CPT or the endothelium-related change in MBF from rest to CPT (DeltaMBF) (0.09 +/- 0.10, 0.11 +/- 0.09, and 0.08 +/- 0.05 ml/g/min; p = NS), and they were linearly correlated (r = 0.72, r = 0.76 and r = 0.84; p < 0.0001). Corresponding values for standard error of the estimate (SEE), as indicative for the range of MBF measurement error, were 0.14, 0.14, and 0.09 ml/g/min. The LR yielded relatively higher but non-significant absolute differences in the MBF at rest, MBF during CPT and DeltaMBF (0.10 +/- 0.10, 0.14 +/- 0.10, and 0.19 +/- 0.10 ml/g/min; p = NS), and paired MBFs significantly correlated (r = 0.75, r = 0.71, and r = 0.60; p < 0.001). Corresponding SEEs were 0.13, 0.15, and 0.16 ml/g/min. The interobserver analysis yielded a high correlation for MBF at rest, MBF during CPT, and hyperemic MBF (r = 0.96, SEE=0.04; r = 0.78, SEE=0.11; and r = 0.87, SEE=0.28; p < 0.0001, respectively), and also a good interobserver correlation for DeltaMBF (r = 0.62, SEE=0.09; p < 0.003).
conclusionShort- and long-term MBF responses to CPT, as an index for endothelium-related coronary vasomotion, can be measured reproducibly with (13)N-ammonia PET. In addition, the high interobserver reproducibility for repeat analysis of MBF values suggests the measurements to be largely operator independent.
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