Evidence map›Paper›PMID 17334649›Full record

ArticleDiabetologia2007

Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes.

S M Gold, I Dziobek, V Sweat, A Tirsi, K Rogers, H Bruehl, W Tsui, S Richardson, E Javier, A Convit

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03414151 (Gut Microbiome and Metabolic Dysfunction in Antipsychotic Naïve Patients), which is not on this map. Cited by 215 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 8 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03414151 active not recruitingnot on this mapstarted 2018, after this paper: background citation

Gut Microbiome and Metabolic Dysfunction in Antipsychotic Naïve Patients

TypeobservationalSponsorCentre for Addiction and Mental HealthRan2018 to 2026Enrolled25ConditionsPsychotic Disorder, SchizophreniaArmsObservation
3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 8 syntheses or guidelines pooled it, 483 citations in OpenAlex.

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  14. MAM-Mediated Mitochondrial CaBrain sciences · 2025
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  17. Journal of diabetes and metabolic disorders · 2025
    Review
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155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

S M GoldDepartment of Psychiatry, New York University School of Medicine, 550 First Avenue, HN-400, New York, NY 10016, USA.
I Dziobek
V Sweat
A Tirsi
K Rogers
H Bruehl
W Tsui
S Richardson
E Javier
A Convit
New York University · USMax Planck Institute for Human Development · DENathan Kline Institute for Psychiatric Research · US

Funding

PSYCHOSOCIAL COREP30AG008051 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUSINEK, HENRY · 1990 to 2019
$36.1M
ZOPOLRESTAT IN SUBJECTS W/ PERIPHERAL SYMMETRICAL DIABETIC POLYNEUROPATHYM01RR000096 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REIBMAN, JOAN · 1985 to 2008
$34.8M
Diabetes, Cognition and the BrainR01DK064087 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CONVIT, ANTONIO · 2003 to 2014
$4.2M
NCRR NIH HHS M01 RR00096NIA NIH HHS P30-AG-08051NIDDK NIH HHS DK064087
6 · The paper itself

Abstract

aims/hypothesisThere is evidence that type 2 diabetes mellitus is associated with cognitive impairment. Most studies investigating this association have evaluated elderly individuals, after many years of diabetes, who generally have poor glycaemic control and significant vascular disease. The aim of the current study was to investigate the early cognitive consequences and associated brain correlates of type 2 diabetes. MATERIALS AND

methodsWith regard to cognition and brain measures, we compared 23 age-, sex- and education-matched control subjects with 23 mostly middle-aged individuals with relatively well-controlled diabetes of less than 10 years from the time of diagnosis.

resultsWe found deficits in hippocampal-based memory performance and preservation of other cognitive domains. Relative to control subjects, individuals with diabetes had reductions in brain volumes that were restricted to the hippocampus. There was an inverse relationship between glycaemic control and hippocampal volume; in multivariate regression analysis, HbA(1c) was the only significant predictor of hippocampal volume, accounting for 33% of the observed variance. Other variables commonly associated with type 2 diabetes, such as elevated BMI, hypertension or dyslipidaemia, did not independently contribute to the variance in hippocampal volume. CONCLUSIONS/

interpretationThese results suggest that the medial temporal lobe may be the first brain site affected by type 2 diabetes and that individuals in poorer metabolic control may be affected to a greater extent.

Indexed as

AgedBrainBrain DiseasesCognitionDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHippocampusHumansMagnetic Resonance ImagingMaleMemory DisordersMiddle AgedNeuropsychological Tests

Identifiers

PMID17334649
OpenAlexW2030265072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.