Trial reportBritish journal of cancer1992
Time to loco-regional recurrence after resection of Dukes' B and C colorectal cancer with or without adjuvant postoperative radiotherapy. A multivariate regression analysis.
Trial report in British journal of cancer, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Effectiveness of radiotherapy for local control in T3N0 rectal cancer managed with total mesorectal excision: a meta-analysis.Oncotarget · 2022Pooled it
- [Prognostic histological markers in colorectal cancer].Pathologie (Heidelberg, Germany) · 2023Review
- Article
- The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection.Mediators of inflammation · 2020Article
- A nomogram to predict vascular invasion before resection of colorectal cancer.Oncology letters · 2019Article
- Development and Validation of a Nomogram for Preoperative Prediction of Perineural Invasion in Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages.BMC cancer · 2018Article
- Laparoscopic total mesorectal excision for extraperitoneal rectal cancer: long-term results of a 18-year single-centre experience.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Article
- Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection.Annals of surgical treatment and research · 2014Article
- Early recurrence in patients undergoing curative surgery for colorectal cancer: is it a predictor for poor overall survival?International journal of colorectal disease · 2013Article
- Patterns of failure in patients with locally advanced rectal cancer receiving pre-operative or post-operative chemoradiotherapy.Radiation oncology (London, England) · 2013Article
- Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively?International journal of colorectal disease · 2012Article
- Article
- Perineural invasion is an independent predictor of outcome in colorectal cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009Article
- Local recurrence and survival after laparoscopic mesorectal resection forrectal adenocarcinoma.Surgical endoscopy · 2002Article
- Assessment of the prognostic factors for a local recurrence of rectal cancer: the utility of preoperative MR imaging.Korean journal of radiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Factors influencing time to loco-regional recurrence were identified in a multivariate regression analysis of data from a series of 468 radically operated patients (260 Dukes' B and 208 Dukes' C) with carcinoma of the rectum and the rectosigmoid. A number of clinical and pathological characteristics were prospectively collected and recorded. In addition, carcinoembryonic antigen (CEA) was measured within 1 week before surgery. The endpoint used was recurrence below the level of the umbilicus. All patients were followed for at least 5 years or until time of death. The two Dukes' stages B and C were analysed in two separate analyses using the Cox proportional hazards model. In patients with Dukes' B tumours, an increased risk of loco-regional recurrence was associated with perineural invasion, tumour located less than 10 cm from the anal verge, patient aged above 70 years, and small tumour size. In patients with Dukes' C tumours, the necessity to resect neighbour organs, perineural and venous invasion, tumour located less than 10 cm from the anal verge, and large tumour size were all associated with a poor loco-regional outcome. Postoperative radiotherapy was not a significant prognosticator for loco-regional control. An update of the 5-year results of the randomised study of post-operative radiotherapy (50 Gy with 2 Gy per fraction in an overall treatment time of 7 weeks) showed no survival benefit from adjuvant radiotherapy in either Dukes' category and no statistically significant improvement in the 5-year loco-regional control rate. However, when the comparison was restricted to a group of high-risk patients there was a statistically significant benefit from radiotherapy with respect to loco-regional control (P = 0.03) but not with respect to survival (P = 0.23). The potential advantage, in terms of the required number of patients, of restricting clinical trials of intensified loco-regional therapies to the high-risk patients, is illustrated.
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